135367-07-6

Basic information

• Product Name: 3β-(4-propionylaminophenyl)tropane-2β-carboxylic acid methyl ester
• Synonyms: 3β-(4-propionylaminophenyl)tropane-2β-carboxylic acid methyl ester
• CAS NO: 135367-07-6
• Molecular Weight: 330.427
• Mol File: 135367-07-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3β-(4-propionylaminophenyl)tropane-2β-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3β-(4-propionylaminophenyl)tropane-2β-carboxylic acid methyl ester(135367-07-6)
• EPA Substance Registry System: 3β-(4-propionylaminophenyl)tropane-2β-carboxylic acid methyl ester(135367-07-6)

Safety Data

• Hazardous Substances Data: 135367-07-6(Hazardous Substances Data)

Upstream product

• 127279-73-6 3β-(4-nitrophenyl)tropane-2β-carboxylic acid methyl ester 
• 50370-54-2 3β-phenyltropane-2β-carboxylic acid methyl ester 
• 50373-10-9 (R)-(-)-anhydroecgonine methyl ester 
• 134052-62-3 3β-(4-aminophenyl)tropane-2β-carboxylic acid methyl ester 
• 123-62-6 propionic acid anhydride 

Relevant articles and documents

Synthesis, ligand binding, QSAR, and CoMFA study of 3β-(p-substituted phenyl)tropane-2β-carboxylic acid methyl esters

A series of 3β-(p-substituted phenyl)tropane-2β-carboxylic acid methyl esters (2) were synthesized and found to possess high affinity for the cocaine binding site in rat striatum. The p-chloro (2c) and p-iodo (2n) compounds, which were the most potent analogues prepared, were found to be 85 and 78 times more potent than (-)-cocaine. The p-bromo (2m) and p-methyl (2d) were also 56 and 60 times more potent than cocaine. QSAR and CoMFA studies were conducted to correlate binding affinity of the cocaine analogues with their structural features. Whereas the QSAR study gave relatively low correlations, the CoMFA study gave a correlation with high predictive value.