1356965-17-7

Basic information

• Product Name: 2-[(1E)-1-(1,3-benzodioxol-5-yl)-4,4-dimethylpent-1-en-3-ylidene]-N-(2-methylphenyl)hydrazinecarboxamide
• Synonyms: 2-[(1E)-1-(1,3-benzodioxol-5-yl)-4,4-dimethylpent-1-en-3-ylidene]-N-(2-methylphenyl)hydrazinecarboxamide
• CAS NO: 1356965-17-7
• Molecular Weight: 379.459
• Mol File: 1356965-17-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-[(1E)-1-(1,3-benzodioxol-5-yl)-4,4-dimethylpent-1-en-3-ylidene]-N-(2-methylphenyl)hydrazinecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(1E)-1-(1,3-benzodioxol-5-yl)-4,4-dimethylpent-1-en-3-ylidene]-N-(2-methylphenyl)hydrazinecarboxamide(1356965-17-7)
• EPA Substance Registry System: 2-[(1E)-1-(1,3-benzodioxol-5-yl)-4,4-dimethylpent-1-en-3-ylidene]-N-(2-methylphenyl)hydrazinecarboxamide(1356965-17-7)

Safety Data

• Hazardous Substances Data: 1356965-17-7(Hazardous Substances Data)

Upstream product

• 75-97-8 3,3-dimethyl-butan-2-one 
• 144850-45-3 (E)-4,4-dimethyl-1-(3,4-methylenedioxyphenyl)pent-1-en-3-one 
• 15940-63-3 4-(2-methylphenyl)semicarbazide 
• 120-57-0 piperonal 
• 5255-71-0 ethyl N-(o-tolyl)carbamate 
• 95-53-4 o-toluidine 
• 139-85-5 3,4-dihydroxybenzaldehyde 

Relevant articles and documents

Design and synthesis of novel stiripentol analogues as potential anticonvulsants

A series of stiripentol (STP) analogues namely, 2-[(1E)-1-(1,3-benzodioxol- 5-yl)-4,4-dimethylpent-1-en-3-ylidene]-N-(aryl/H)hydrazinecarboxamides 7a-h, (±)-(5RS)-N-(aryl/H)-(1,3-benzodioxol-5-yl)-3-tert-butyl-4, 5-dihydro-1H-pyrazole-1-carboxamides (±)-8a-h, and (±)-[(5RS)-(1, 3-benzodioxol-5-yl)-3-tert-butyl-4,5-dihydro-1H-pyrazol-1-yl](aryl)methanones (±)-13a-f was synthesized by adopting appropriate synthetic routes and was pharmacologically evaluated in the preliminary anticonvulsant screens. The selected bioactive new chemical entities were subjected to ED50 determination and neurotoxicity evaluation. The most active congeners are 7h in MES screen and (±)-13b in scPTZ screen which displayed ED50 values of 87 and 110 mg/kg, respectively, as compared to that of STP (ED 50 = 277.7 and 115 mg/kg in MES and scPTZ, respectively).