5255-71-0

Basic information

• Product Name: 2-(METHYLPHENYL) CARBAMIC ACID ETHYL ESTER
• Synonyms: 2-(METHYLPHENYL) CARBAMIC ACID ETHYL ESTER;Ethyl 2-methylphenylcarbamate;Ethyl N-(2-methylphenyl)carbamate;NSC44949;ETHYL N-(O-TOLYL)CARBAMATE
• CAS NO: 5255-71-0
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.22
• Mol File: 5255-71-0.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 222.9 °C at 760 mmHg
• Flash Point: 88.6 °C
• Appearance: /
• Density: 1.108g/cm³
• Vapor Pressure: 0.0991mmHg at 25°C
• Refractive Index: 1.552
• CAS DataBase Reference: 2-(METHYLPHENYL) CARBAMIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(METHYLPHENYL) CARBAMIC ACID ETHYL ESTER(5255-71-0)
• EPA Substance Registry System: 2-(METHYLPHENYL) CARBAMIC ACID ETHYL ESTER(5255-71-0)

Safety Data

• Hazardous Substances Data: 5255-71-0(Hazardous Substances Data)

Usage

General Description

2-(Methylphenyl) carbamic acid ethyl ester, also known as ethyl 2-(methylphenyl)carbamate, is a chemical compound that belongs to the class of carbamic acid esters. It is synthesized by the reaction of 2-(methylphenyl) isocyanate with ethanol. 2-(METHYLPHENYL) CARBAMIC ACID ETHYL ESTER is commonly used as an intermediate in the production of pharmaceuticals, agrochemicals, and other organic compounds. It has potential applications in the synthesis of pesticides, herbicides, and pharmaceutical drugs. The compound is a colorless to pale yellow liquid with a characteristic odor, and it is considered to be a relatively stable and non-reactive compound under normal conditions. However, it should be handled with caution and proper safety measures due to its potential for toxicity and irritant effects.

InChI:InChI=1/C10H13NO2/c1-3-13-10(12)11-9-7-5-4-6-8(9)2/h4-7H,3H2,1-2H3,(H,11,12)

Upstream product

• 64-17-5 ethanol 
• 16080-08-3 (2-methylphenyl)carbonimidic dichloride 
• 141-52-6 sodium ethanolate 
• 541-41-3 chloroformic acid ethyl ester 
• 95-53-4 o-toluidine 
• 60-29-7 diethyl ether 
• 100-61-8 N-methylaniline 
• 201230-82-2 carbon monoxide 
• 88-72-2 1-methyl-2-nitrobenzene 
• 614-69-7 2-tolyl isothiocyanate 
• 636-21-5 o-toluidine hydrochloride 
• 5408-04-8 ethyl 2-hydroxyimino-3-oxobutanoate 
• 1202047-19-5 1-tert-butyl-1-isopropyl-3-phenylurea 
• 74-88-4 methyl iodide 

Downstream Products

• 13140-49-3 N-(2-methylphenyl)-N'-phenylurea 
• 617-07-2 N,N'-bis(2-methylphenyl)urea 
• 614-68-6 2-tolyl isocyanate 
• 15940-63-3 4-(2-methylphenyl)semicarbazide 
• 1356965-25-7 (5RS)-5-(benzo[d][1,3]dioxol-5-yl)-3-tert-butyl-N-(2-methylphenyl)-4,5-dihydro-1H-pyrazole-1-carboxamide 
• 1356965-17-7 2-[(1E)-1-(1,3-benzodioxol-5-yl)-4,4-dimethylpent-1-en-3-ylidene]-N-(2-methylphenyl)hydrazinecarboxamide 
• 128886-52-2 ((2S,3R)-3-Hydroxymethyl-oxiranylmethyl)-o-tolyl-carbamic acid ethyl ester 
• 128886-52-2 ((2S,3S)-3-Hydroxymethyl-oxiranylmethyl)-o-tolyl-carbamic acid ethyl ester 
• 128886-62-4 (R)-5-((S)-1,2-Dihydroxy-ethyl)-3-o-tolyl-oxazolidin-2-one 
• 128886-62-4 (R)-5-((R)-1,2-Dihydroxy-ethyl)-3-o-tolyl-oxazolidin-2-one 
• 128910-60-1 ((E)-4-Hydroxy-but-2-enyl)-o-tolyl-carbamic acid ethyl ester 
• 128886-46-4 ((Z)-4-Hydroxy-but-2-enyl)-o-tolyl-carbamic acid ethyl ester 
• 35600-65-8 Chloromethyl-o-tolyl-carbamic acid ethyl ester 

Relevant articles and documents

An efficient one-pot synthesis of: N, N ′-disubstituted ureas and carbamates from N -acylbenzotriazoles

A facile and high-yielding one-pot synthesis of carbamates and N,N′-disubstituted symmetrical ureas from N-acylbenzotriazoles has been devised. It is believed that, the intermediate acyl-azide undergo Curtius rearrangement and in different solvents gives different products i.e. carbamates in alcohols and N,N′-disubstituted symmetrical urea in THF.

Facile double-lithiation of a transient urea: Vicarious ortho -metalation of aniline derivatives

A convenient one-pot method for the conversion of phenylisocyanate into ortho-functionalized aniline derivatives has been developed. The reaction proceeds via the selective ortho-metalation of a transient labile urea, which can be considered as a synthetic equivalent of 2-lithio-phenylisocyanate, a highly improbable intermediate.

Pyrazolinols

The use of pyrazolinols formula (I) in which A, Q, R1, R2, R3, R4 and R5 are as defined in the description for controlling pests, novel pyrazolinols and a plurality of processes for preparing these co