13570-00-8

Basic information

• Product Name: 3-(1H-IMIDAZOL-2-YL)-PYRIDINE
• Synonyms: 3-(1H-IMIDAZOL-2-YL)-PYRIDINE;3-(1H-imidazol-2-yl)pyridine(SALTDATA: FREE);3-(IMIDAZOL-2-YL)-PYRIDINE
• CAS NO: 13570-00-8
• Molecular Formula: C₈H₇N₃
• Molecular Weight: 145.16
• Mol File: 13570-00-8.mol
• Article Data: 13

Chemical Properties

• Melting Point: 196-198 °C
• Boiling Point: 384.927 °C at 760 mmHg
• Flash Point: 192.737 °C
• Appearance: /
• Density: 1.215 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.611
• PKA: 12.20±0.10(Predicted)
• CAS DataBase Reference: 3-(1H-IMIDAZOL-2-YL)-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1H-IMIDAZOL-2-YL)-PYRIDINE(13570-00-8)
• EPA Substance Registry System: 3-(1H-IMIDAZOL-2-YL)-PYRIDINE(13570-00-8)

Safety Data

• Hazardous Substances Data: 13570-00-8(Hazardous Substances Data)

Usage

General Description

3-(1H-imidazol-2-yl)-pyridine is a chemical compound with the molecular formula C8H7N3. It is a heterocyclic aromatic compound consisting of a pyridine ring fused to an imidazole ring. 3-(1H-IMIDAZOL-2-YL)-PYRIDINE is commonly used in organic synthesis and pharmaceutical research, as it serves as a building block for the preparation of various biologically active molecules. It has also been studied for its potential as an anti-inflammatory and antiviral agent. Additionally, 3-(1H-imidazol-2-yl)-pyridine is used as a ligand in coordination chemistry, forming complexes with various metal ions. It is a pale yellow crystalline powder with a molecular weight of 133.16 g/mol and a melting point of 134-136°C.

InChI:InChI=1/C8H7N3/c1-2-7(6-9-3-1)8-10-4-5-11-8/h1-6H,(H,10,11)

Upstream product

• 59-67-6 nicotinic acid 
• 107-15-3 ethylenediamine 
• 110-86-1 pyridine 
• 50846-98-5 2-Diazo-2H-imidazole 
• 148747-91-5 N-(2,2-dimethoxyethyl)-3-pyridinecarboxamidine 
• 100-54-9 pyridine-3-carbonitrile 
• 22483-09-6 2,2-dimethoxyethylamine 
• 6302-53-0 2-(pyridin-3-yl)imidazoline 

Relevant articles and documents

Novel and chemoselective dehydrogenation of 2-substituted imidazolines with potassium permanganate supported on silica gel

Various types of 2-imidazolines are efficiently oxidized to the corresponding imidazoles using potassium permanganate supported on silica gel under mild conditions at room temperature. 2-Alkylimidazolines are selectively converted to their corresponding imidazoles in the presence of 2-arylimidazolines. Chemoselective oxidation of 2-imidazolines in the presence of other oxidizable functional groups such as sulfide, ether, aldehyde, acetal, and THP ether was also achieved by this reagent system.

Dehydrogenation of 2-imidazolines with sodium periodate catalyzed by manganese(III) tetraphenylporphyrin

In the present work, dehydrogenation of 2-substituted imidazolines with sodium periodate in the presence of tetraphenylporphyrinatomanganese(III) chloride, [Mn(TPP)Cl], is reported. A wide variety of 2-imidazolines efficiently converted to their corresponding imidazoles by [Mn(TPP)Cl]/NaIO4 catalytic system at room temperature in 1:2, CH3CN/H2O mixture. The effect of reaction parameters such as kind of solvent and catalyst amount was also investigated.

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Multi-wall carbon nanotube supported manganese(III) porphyrin: An efficient and reusable catalyst for oxidation of 2-imidazolines with sodium periodate

The oxidation of 2-substituted imidazolines with sodium periodate catalyzed by tetrakis(p-aminophenyl)-porphyrinatomanganese(III) chloride, [Mn(TNH 2PP)Cl], supported on functionalized multi-wall carbon nanotubes is reported. A wide variety of 2-imidazolines were efficiently converted to their corresponding imidazoles by this catalytic system. When the same reaction was subjected to ultrasonic irradiation, the reaction times were reduced significantly and the product yields were increased. This catalyst could be reused several times without significant loss of activity. The effects of reaction parameters such catalyst amount, choice of solvent, and the effects of ultrasonic irradiation on the catalytic activity have been investigated.

Stabilizing volatile liquid chemicals using co-crystallization

A convenient, effective, and scalable protocol for stabilizing volatile liquid chemicals is reported. Through the use of halogen-bond driven co-crystal synthesis, several examples of liquid iodoperfluoroalkanes are transformed into crystalline materials with low-vapor pressure, considerable thermal stability, and moisture resistance. The target compounds can subsequently be re-generated through simple solvent-extractions.