135833-82-8

Basic information

• Product Name: 1-(4-Fluorophenyl)-5-methyl-2-phenylhexane-1,4-dione
• Synonyms: 1-(4-Fluorophenyl)-5-methyl-2-phenylhexane-1,4-dione;1,4-Hexanedione, 1-(4-fluorophenyl)-5-methyl-2-phenyl-;1-(4-fluorophenyl)-5-methyl-2-phenyl-1,4-Hexanedione
• CAS NO: 135833-82-8
• Molecular Formula: C₁₉H₁₉FO₂
• Molecular Weight: 298.3513632
• Mol File: 135833-82-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(4-Fluorophenyl)-5-methyl-2-phenylhexane-1,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-Fluorophenyl)-5-methyl-2-phenylhexane-1,4-dione(135833-82-8)
• EPA Substance Registry System: 1-(4-Fluorophenyl)-5-methyl-2-phenylhexane-1,4-dione(135833-82-8)

Safety Data

• Hazardous Substances Data: 135833-82-8(Hazardous Substances Data)

Usage

General Description

1-(4-Fluorophenyl)-5-methyl-2-phenylhexane-1,4-dione, also known as 4'-fluoro-α-pyrrolidinohexiophenone or 4'-fluoro-α-pyrrolidinohexanophenone, is a chemical compound that belongs to the class of cathinones, a type of stimulant drug. It is a derivative of α-PVP and has similar effects to other stimulant substances, such as increased energy, euphoria, and heightened sensory perception. The chemical structure of 1-(4-Fluorophenyl)-5-methyl-2-phenylhexane-1,4-dione contains a phenyl group, a ketone group, and a fluorine atom, which are responsible for its psychoactive properties. 1-(4-Fluorophenyl)-5-methyl-2-phenylhexane-1,4-dione has been reported as a designer drug and is considered to have a high potential for abuse and dependence. Its long-term effects on human health are not well-studied, and it is often regulated as a controlled substance in many countries due to its potential for misuse.

Upstream product

• 563-80-4 3-methyl-butan-2-one 
• 347-84-2 1-(4-fluorophenyl)-2-phenylethanone 
• 19967-55-6 1-bromo-3-methyl-2-butanone 
• 912998-82-4 (+/-)methyl 2-(2-(4-fluorophenyl)-2-oxo-1-phenylethyl)-4-methyl-3-oxopentanoate 
• 100-52-7 benzaldehyde 
• 42558-54-3 Methyl 4-methyl-3-oxopentanoate 
• 459-57-4 4-fluorobenzaldehyde 
• 912998-81-3 methyl 4-methyl-3-oxo-2-(phenylmethylene)pentanoate 

Downstream Products

• 1262052-11-8 1-(2-{(4R,6S)-6-[2-(benzyloxy)ethyl]-2,2-dimethyl-1,3-dioxan-4-yl}ethyl)-2-(4-fluorophenyl)-5-isopropyl-3-phenyl-1H-pyrrole 
• 1026685-96-0 tert-butyl 2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-1H-pyrrol-1-yl)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate 
• 135834-14-9 (4R,6R)-6-{2-[2-(4-Fluoro-phenyl)-5-isopropyl-3-phenyl-pyrrol-1-yl]-ethyl}-4-hydroxy-tetrahydro-pyran-2-one 
• 135834-02-5 3-[2-(4-Fluoro-phenyl)-5-isopropyl-3-phenyl-pyrrol-1-yl]-propionaldehyde 
• 135833-83-9 1-(3,3-diethoxypropyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-1H-pyrrole 

Relevant articles and documents

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Inhibitors of Cholesterol Biosynthesis. 3. Tetrahydro-4-hydroxy-6--2H-pyran-2-one Inhibitors of HMG-CoA Reductase. 2. Effects of Introducing Substituents at Positions Three and Four of the Pyrrole Nucleus

A series of trans-tetrahydro-4-hydroxy-6--2H-pyran-2 ones and their dihydroxy acids were prepared and tested for their ability to inhibit the enzyme HMG-CoA reductase in vitro.Inhibitory potency was found to increase subtantially when substituents were introduced into positions three and four of the pyrrole ring.A systematic exploration of structure-activity relationships at these two positions led to the identification of a compound ((+)-33, (+)-(4R)-trans-2-(4-fluorophenyl)-5-(1-methylethyl)-N,3-diphenyl-1- -1H-pyrrole-4-carboxamide) with five times the inhibitory potency of the fungal metabolite compactin.