135855-62-8

Basic information

• Product Name: 1H-Indol-6-amine,1-methyl-(9CI)
• Synonyms: 1H-Indol-6-amine,1-methyl-(9CI);6-Amino-1-methylindole;1-Methyl-1H-indol-6-aMine;1H-Indol-6-aMine, 1-Methyl-;(1-Methylindol-6-yl)amine;(1-Methyl-1H-indol-6-yl)amine
• CAS NO: 135855-62-8
• Molecular Formula: C₉H₁₀N₂
• Molecular Weight: 146.192
• Product Categories: AMINEPRIMARY
• Mol File: 135855-62-8.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 328.036°C at 760 mmHg
• Flash Point: 152.191°C
• Appearance: /
• Density: 1.151g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.62
• Storage Temp.: 2-8°C(protect from light)
• PKA: 5.30±0.10(Predicted)
• CAS DataBase Reference: 1H-Indol-6-amine,1-methyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indol-6-amine,1-methyl-(9CI)(135855-62-8)
• EPA Substance Registry System: 1H-Indol-6-amine,1-methyl-(9CI)(135855-62-8)

Safety Data

• Hazardous Substances Data: 135855-62-8(Hazardous Substances Data)

Usage

General Description

1H-Indol-6-amine,1-methyl-(9CI) is a chemical compound with the molecular formula C9H10N2. It is an indole amine derivative with a methyl group attached to the nitrogen atom at position 1 of the indole ring. 1H-Indol-6-amine,1-methyl-(9CI) is a pale yellow to brown solid that is soluble in organic solvents but insoluble in water. It is commonly used in organic synthesis and pharmaceutical research as a precursor for the synthesis of various other compounds. It has also been studied for its potential pharmacological properties, including its role as a potential antiviral and antitumor agent. However,

InChI:InChI=1/C9H10N2/c1-11-5-4-7-2-3-8(10)6-9(7)11/h2-6H,10H2,1H3

Upstream product

• 2380-84-9 7-Indolol 
• 20289-27-4 7-benzyloxyindole 
• 475577-34-5 7-benzyloxy-1-methyl-1H-indole 
• 475577-33-4 7-hydroxy-1-methyl-1H-indole 
• 4769-96-4 6-nitroindole 
• 99459-48-0 1-methyl-6-nitro-indole 

Relevant articles and documents

One-Pot Generation of Benzynes from Phenols: Formation of Primary Anilines by the Deoxyamination of Phenols

Benzynes were selectively generated in situ from phenols and trapped regioselectively with potassium hexamethyldisilazide to form primary anilines following acidic workup. The direct conversion of a phenolic hydroxyl group into a free amino group is a useful method for the preparation of primary aryl amines that are hard to synthesize by using coupling reactions involving phenol derivatives with ammonia. Whereas reactions of ortho- and meta-substituted phenols produced meta-substituted anilines exclusively, those of para-substituted phenols provided ortho-silylanilines.

Structure-based design and synthesis of 2,4-diaminopyrimidines as EGFR L858R/T790M selective inhibitors for NSCLC

Mutated epidermal growth factor receptor (EGFR) is a major driver of non-small cell lung cancer (NSCLC). The EGFRT790M secondary mutation has become a leading cause of clinically-acquired resistance to gefitinib and erlotinib. Herein, we present a structure-based design approach to increase the potency and selectivity of the previously reported reversible EGFR inhibitor 7, at the kinase and cellular levels. Three-step structure-activity relationship exploration led to promising compounds 19e and 19h with unique chemical structure and binding mode from the other third-generation tyrosine kinase inhibitors. In a human NSCLC xenograft model, 19e and 19h exhibited dose-dependent tumor growth suppression without toxicity. These selective inhibitors are promising drug candidates for EGFRT790M-driven NSCLC.

NOVEL AMINE DERIVATIVE OR SALT THEREOF

A novel amine derivative expressed by general formula (1) (in the formula: G1, G2, and G3 are the same or different and represent CH or a nitrogen atom; R1 represents a chlorine atom, an optionally-substituted C3-8 cycloalkyl group, or the like; R2 represents -COOR5 (in the formula, R5 represents a hydrogen atom or a carboxyl protective group), or the like; R3 represents a hydrogen atom, or the like; and R4 represents an optionally-substituted condensed bicyclic hydrocarbon group, an optionally-substituted bicyclic heterocyclic group, or the like), or a salt thereof is useful in procedures such as the treatment or prevention of conditions related to excessive keratinocyte proliferation.