99459-48-0

Basic information

• Product Name: 1H-Azepine-2,4(3H,5H)-dione, dihydro-1-(phenylmethyl)-
• CAS NO: 99459-48-0
• Molecular Formula: C13H15NO2
• Molecular Weight: 176.175
• Mol File: 99459-48-0.mol
• Article Data: 31

Chemical Properties

• CAS DataBase Reference: 1H-Azepine-2,4(3H,5H)-dione, dihydro-1-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Azepine-2,4(3H,5H)-dione, dihydro-1-(phenylmethyl)-(99459-48-0)
• EPA Substance Registry System: 1H-Azepine-2,4(3H,5H)-dione, dihydro-1-(phenylmethyl)-(99459-48-0)

Safety Data

• Hazardous Substances Data: 99459-48-0(Hazardous Substances Data)

Usage

General Description

1H-Azepine-2,4(3H,5H)-dione, dihydro-1-(phenylmethyl)-, also known as Riluzole, is a chemical compound used as a treatment for amyotrophic lateral sclerosis (ALS). It works by regulating the release of glutamate, a neurotransmitter in the brain that is thought to play a role in the progression of ALS. Riluzole is believed to slow down the damage to motor neurons and slow the progression of the disease. It is available in tablet form for oral administration and is generally well-tolerated, although it may cause side effects such as dizziness, nausea, and weakness. Riluzole has been approved by the U.S. Food and Drug Administration for use in the treatment of ALS, and it is considered an important medication for managing the symptoms and progression of the disease.

Upstream product

• 115210-53-2 1-methyl-6-nitroindoline 
• 603-76-9 1-methylindole 
• 19727-83-4 6-nitroindoline 
• 4769-96-4 6-nitroindole 
• 74-88-4 methyl iodide 
• 616-38-6 carbonic acid dimethyl ester 
• 824-21-5 N-methylindoline 

Downstream Products

• 135855-62-8 1-methyl-1H-indol-6-ylamine 
• 125313-92-0 3-(1-methyl-3-indolyl)-4-(1-methyl-6-nitro-3-indolyl)-1H-pyrrole-2,5-dione 
• 184161-65-7 2-(1-methyl-6-nitro-7-indolyl)ethanol 
• 184161-63-5 (1-methyl-6-nitroindol-7-yl)acetonitrile 
• 120627-56-7 1-Methyl-6-nitro-7-(toluene-4-sulfonylmethyl)-1H-indole 

Relevant articles and documents

Ir-Catalyzed Reversible Acceptorless Dehydrogenation/Hydrogenation of N-Substituted and Unsubstituted Heterocycles Enabled by a Polymer-Cross-Linking Bisphosphine

The polystyrene-cross-linking bisphosphine ligand PS-DPPBz was effective for the Ir-catalyzed reversible acceptorless dehydrogenation/hydrogenation of N-heterocycles. Notably, this protocol is applicable to the dehydrogenation of N-substituted indoline derivatives with various N-substituents with different electronic and steric natures. A reaction pathway involving oxidative addition of an N-adjacent C(sp3)-H bond to a bisphosphine-coordinated Ir(I) center is proposed for the dehydrogenation of N-substituted substrates.

PYRROLOINDOLE DERIVATIVES AND METHOD OF PRODUCING THEM

PROBLEM TO BE SOLVED: To provide a hydrogen acceptor capable of storing and releasing hydrogen, and a hydrogen donor conjugate therewith. SOLUTION: The invention provides pyrroloindole derivatives represented by general formula (1) (where R1 represents a C1-4 alkyl group, and R2 represents a hydrogen atom or C1-4 alkyl group; and a double line of a broken line and a solid line represents a single bond or double bond). Also provided are methods of producing them. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT

HEPARAN SULFATE BIOSYNTHESIS INHIBITORS FOR THE TREATMENT OF DISEASES

Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions in need of inhibition of heparan sulfate biosynthesis.