135947-75-0

Basic information

• Product Name: MK 287
• Synonyms: MK 287
• CAS NO: 135947-75-0
• Molecular Formula: C₂₅H₃₄O₉S
• Molecular Weight: 510.59706
• Mol File: 135947-75-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 684°Cat760mmHg
• Flash Point: 367.5°C
• Appearance: /
• Density: 1.224g/cm³
• Vapor Pressure: 1.2E-19mmHg at 25°C
• Refractive Index: 1.537
• CAS DataBase Reference: MK 287(CAS DataBase Reference)
• NIST Chemistry Reference: MK 287(135947-75-0)
• EPA Substance Registry System: MK 287(135947-75-0)

Safety Data

• Hazardous Substances Data: 135947-75-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C25H34O9S/c1-6-10-33-25-22(31-4)14-17(15-23(25)35(27,28)11-9-26)19-8-7-18(34-19)16-12-20(29-2)24(32-5)21(13-16)30-3/h12-15,18-19,26H,6-11H2,1-5H3/t18-,19-/m0/s1

Upstream product

• 140705-19-7 (S)-5-[3-(2-Hydroxy-ethanesulfonyl)-5-methoxy-4-propoxy-phenyl]-dihydro-furan-2-one 
• 133095-92-8 4-(3-Iodo-5-methoxy-4-propoxy-phenyl)-4-oxo-butyric acid tert-butyl ester 
• 133095-94-0 (S)-4-Hydroxy-4-(3-iodo-5-methoxy-4-propoxy-phenyl)-butyric acid 
• 133095-95-1 4[3-Methoxy-4-n-propyloxy-5-iodophenyl]-4S-butyrolactone 
• 481725-17-1 (1R,2S,3S,5S,6R,7S)-4,10-dioxa-3-[3-methoxy-5-(2'-t-butyldimethylsilyloxyethanesulfanyl)-4-propoxy]-5-[(3',4',5')-trimethoxyphenyl]-tricyclo[5.2.1.0^2,6]dec-8-en-3-ol 
• 481725-18-2 (1R,2S,3S,5S,6R,7S)-4,10-dioxa-3-[3-methoxy-5-(2'-t-butyldimethylsilyloxyethanesulfanyl)-4-propoxy]-5-[(3',4',5')-trimethoxyphenyl]-tricyclo[5.2.1.0^2,6]dec-8-ene 
• 481725-20-6 (2S,5S)-2-(3',4',5'-trimethoxyphenyl)-5-[3-methoxy-5-(2'-t-butyldimethylsilyloxyethanesulfanyl)-4-propoxyphenyl]tetrahydrofuran 
• 481725-19-3 (2S,5S)-2-(3',4',5'-trimethoxyphenyl)-5-[3-methoxy-5-(2'-t-butyldimethylsilyloxyethanesulfanyl)-4-propoxyphenyl]-2,5-dihydrofuran 
• 481725-15-9 (S)-((1S,2S,3R,4R)-3-Hydroxymethyl-7-oxa-bicyclo[2.2.1]hept-5-en-2-yl)-(3,4,5-trimethoxy-phenyl)-methanol 
• 481725-11-5 1-bromo-3-methoxy-4-propoxy-5-(2'-tert-butyldimethylsilyloxyethanesulfanyl)benzene 
• 481725-16-0 (1R,2S,5S,6R,7S)-5-[(3',4',5')-trimethoxyphenyl]-4,10-dioxatricyclo[5.2.1.0^2,6]dec-8-en-3-one 
• 481725-13-7 1-bromo-3-methoxy-4-propoxy-5-(2'-hydroxyethanesulfanyl)benzene 
• 481725-12-6 1-bromo-3-methoxy-4-propoxy-5-iodobenzene 
• 145399-74-2 3-methoxy-4-propoxy-5-iodobenzoic acid 

Related news

Synthesis and biological activity of MK 287 (cas 135947-75-0) (L-680,573): a potent, specific and orally active paf receptor antagonist08/20/2019

An enantioselective synthesis of MK 287 (L-680,573), a member of a family of trans-,5-diaryltetrahydrofurans, and its biological activity are described.detailed

Relevant articles and documents

Enantioselective synthesis of the PAF antagonist MK-287

Following a general method of synthesis of optically active 2,5-disubstituted tetrahydrofurans, an enantioselective synthesis of the PAF antagonist, MK-287 is described.