1361024-33-0 Usage
Description
C44H40N6O3, also known as 2-Butyl-1,6-dihydro-4-methyl-6-oxo-1-[[2''-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1''-biphenyl]-4-yl]methyl]-5-pyrimidineacetic Acid, is an impurity found in Fimasartan and serves as a reagent in the synthesis and antihypertensive activity of pyrimidin-4(3H)-one derivatives, such as losartan analogues. It is a complex organic compound with a molecular structure that contributes to its various applications in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
C44H40N6O3 is used as an impurity in the production of Fimasartan, an antihypertensive medication. Its presence is crucial for the synthesis process and contributes to the development of the drug's antihypertensive properties.
Used in Research and Development:
C44H40N6O3 is used as a reagent in the synthesis of pyrimidin-4(3H)-one derivatives, such as losartan analogues. These analogues are essential for the development of new antihypertensive medications and the study of their mechanisms of action.
Used in Quality Control:
C44H40N6O3 is used as a reference compound in the quality control process of Fimasartan production. Its identification and quantification help ensure the purity and efficacy of the final product, contributing to the safety and effectiveness of the medication.
Check Digit Verification of cas no
The CAS Registry Mumber 1361024-33-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,6,1,0,2 and 4 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1361024-33:
(9*1)+(8*3)+(7*6)+(6*1)+(5*0)+(4*2)+(3*4)+(2*3)+(1*3)=110
110 % 10 = 0
So 1361024-33-0 is a valid CAS Registry Number.
1361024-33-0Relevant articles and documents
Synthesis and antihypertensive activity of pyrimidin-4(3H)-one derivatives as losartan analogue for new angiotensin II receptor type 1 (AT1) antagonists
Kim, Tae Woo,Yoo, Byoung Wook,Lee, Joon Kwang,Kim, Ji Han,Lee, Kyung-Tae,Chi, Yong Ha,Lee, Jae Yeol
, p. 1649 - 1654 (2012/04/04)
The discovery, in vitro and in vivo studies of the highly potent AT1 antagonist 12a (BR-A-657, Fimasartan) are presented. A series of pyrimidin-4(3H)-one derivatives as losartan analogue were synthesized and evaluated for a novel class of AT1 receptor antagonists. Among them, 12a containing thioamido moiety displayed both high in vitro functional antagonism and binding affinity [IC50 = 0.42 and 0.13 nM, respectively] and inhibited strongly in vivo AngII-induced pressor response in pithed rats with an ED50 of 0.018 mg/kg. Moreover, in vivo evaluation in furosemide-treated rat and conscious renal hypertensive rat models and the pharmacokinetic study showed that 12a is a highly potent and orally active AT1 selective antagonist having stronger in vivo potency than losartan.
