503155-66-6

Basic information

• Product Name: C₄₆H₄₄N₆O₃
• Synonyms: C₄₆H₄₄N₆O₃
• CAS NO: 503155-66-6
• Molecular Weight: 728.894
• Mol File: 503155-66-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₄₆H₄₄N₆O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₆H₄₄N₆O₃(503155-66-6)
• EPA Substance Registry System: C₄₆H₄₄N₆O₃(503155-66-6)

Safety Data

• Hazardous Substances Data: 503155-66-6(Hazardous Substances Data)

Usage

General Description

The chemical "C46H44N6O3" is a complex organic compound with a molecular formula composed of 46 atoms of carbon, 44 atoms of hydrogen, 6 atoms of nitrogen, and 3 atoms of oxygen. This chemical compound is classified as a complex organic molecule and may belong to a class of compounds such as a large organic molecule or a natural product. Its exact structure and properties would need to be determined through experimental analysis and may have potential applications in pharmaceuticals, polymers, and other areas of research and development.

Upstream product

• 503155-65-5 C₁₃H₂₀N₂O₃ 
• 124750-51-2 N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole 

Downstream Products

• 178554-39-7 C₃₁H₃₅N₇O₄ 
• 178554-40-0 C₃₀H₃₄N₈O₃ 
• 178554-73-9 C₃₀H₃₆N₈O₂ 
• 178554-72-8 C₂₉H₃₃N₇O₂S 
• 1027039-09-3 C₃₁H₃₇N₇O₃ 
• 247257-48-3 Fimasartan 
• 247257-49-4 C₂₉H₃₅N₇OS 
• 1347905-46-7 C₃₁H₃₇N₇OS 
• 1361024-33-0 C₄₄H₄₀N₆O₃ 
• 503155-67-7 2-n-butyl-5-dimethylaminocarbonylmethyl-6-methyl-3-[[2'-(N-triphenylmethyltetrazol-5-yl)biphenyl-4-yl]methyl]pyrimidin-4(3H)-one 
• 1361024-36-3 C₄₈H₄₉N₇O₂ 
• 1361024-38-5 C₄₈H₄₇N₇O₂ 
• 1361024-39-6 C₅₀H₄₉N₇O₄ 
• 1361024-40-9 C₄₉H₄₈N₈O₃ 

Relevant articles and documents

Synthesis and antihypertensive activity of pyrimidin-4(3H)-one derivatives as losartan analogue for new angiotensin II receptor type 1 (AT1) antagonists

The discovery, in vitro and in vivo studies of the highly potent AT1 antagonist 12a (BR-A-657, Fimasartan) are presented. A series of pyrimidin-4(3H)-one derivatives as losartan analogue were synthesized and evaluated for a novel class of AT1 receptor antagonists. Among them, 12a containing thioamido moiety displayed both high in vitro functional antagonism and binding affinity [IC50 = 0.42 and 0.13 nM, respectively] and inhibited strongly in vivo AngII-induced pressor response in pithed rats with an ED50 of 0.018 mg/kg. Moreover, in vivo evaluation in furosemide-treated rat and conscious renal hypertensive rat models and the pharmacokinetic study showed that 12a is a highly potent and orally active AT1 selective antagonist having stronger in vivo potency than losartan.