13618-48-9

Basic information

• Product Name: methyl-2-(benzyloxy)-4-methoxybenzoate
• Synonyms: methyl-2-(benzyloxy)-4-methoxybenzoate
• CAS NO: 13618-48-9
• Molecular Weight: 272.301
• Mol File: 13618-48-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: methyl-2-(benzyloxy)-4-methoxybenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl-2-(benzyloxy)-4-methoxybenzoate(13618-48-9)
• EPA Substance Registry System: methyl-2-(benzyloxy)-4-methoxybenzoate(13618-48-9)

Safety Data

• Hazardous Substances Data: 13618-48-9(Hazardous Substances Data)

Upstream product

• 5446-02-6 4-methoxymethylsalicylate 
• 100-44-7 benzyl chloride 
• 2150-47-2 methyl 2,4-dihydroxybenzoate 
• 89-86-1 4-hydroxysalicylic acid 
• 100-39-0 benzyl bromide 

Downstream Products

• 744210-34-2 7-hydroxy-2-(2,4,6-trihydroxy-phenyl)-chromen-4-one 
• 520-30-9 norartocarpetin 
• 744210-77-3 7-methoxy-2-(2,4,6-trimethoxy-phenyl)-chromen-4-one 
• 1448816-33-8 2-(benzyloxy)-4-methoxy-N-(3,4,5-trimethoxyphenyl)benzamide 
• 1448816-36-1 1-(2-(benzyloxy)-3,4,5-trimethoxyphenyl)-5-(2-(benzyloxy)-4-methoxyphenyl)-1H-tetrazole 
• 1448816-38-3 5-(2-(benzyloxy)-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)-1H-tetrazole 
• 1448816-24-7 5-methoxy-2-(1-(3,4,5-trimethoxyphenyl)-1H-tetrazol-5-yl)phenol 
• 13618-49-0 2-(benzyloxy)-4-methoxybenzoic acid 
• 1448816-31-6 2-(benzyloxy)-N-(2-(benzyloxy)-3,4,5-trimethoxyphenyl)-4-methoxybenzamide 
• 1448816-22-5 (6-(2-hydroxy-4-methoxyphenyl)-1H-tetrazol-1-yl)-2,3,4-trimethoxyphenol 
• 856814-55-6 1-(2-benzyloxy-4-methoxy-phenyl)-3-(2,4,6-trimethoxy-phenyl)-propane-1,3-dione 
• 77184-82-8 1-(2-hydroxy-4-methoxyphenyl)-2-phenylethanedione 

Relevant articles and documents

Total synthesis of Neocosmosin A

An alternative synthetic route to (?)-Neocosmosin A has been synthesized from commercially available (R)-propylene oxide and 4-Methoxysalicylic acid as starting materials. The key steps involved in the synthesis are alkylation of 1,3-dithiane and Yamaguchi macrolactonization.

Lipidated Brartemicin Analogues Are Potent Th1-Stimulating Vaccine Adjuvants

Effective Th1-stimulating vaccine adjuvants typically activate antigen presenting cells (APCs) through pattern recognition receptors (PRRs). Macrophage inducible C-type lectin (Mincle) is a PRR expressed on APCs and has been identified as a target for Th1-stimulating adjuvants. Herein, we report on the synthesis and adjuvanticity of rationally designed brartemicin analogues containing long-chain lipids and demonstrate that they are potent Mincle agonists that activate APCs to produce inflammatory cytokines in a Mincle-dependent fashion. Mincle binding, however, does not directly correlate to a functional immune response. Mutation studies indicated that the aromatic residue of lead compound 9a has an important interaction with Mincle Arg183. In vivo assessment of 9a highlighted the capability of this analogue to augment the Th1 response to a model vaccine antigen. Taken together, our results show that lipophilic brartemicin analogues are potent Mincle agonists and that 9a has superior in vivo adjuvant activity compared to TDB.

Benzamide derivatives

Benzamide derivatives of the formula:- STR1 wherein R1 represents a fluorine, chlorine or bromine atom, or an alkyl, alkoxy, alkylthio, alkylsulphonyl, alkanoylamino, alkylamino or alkylsulphamoyl group, each such group containing from 1 to 6 carbon atoms, a dialkylsulphamoyl, dialkylamino or dialkylcarbamoyl group (wherein the two alkyl groups may be the same or different and each contains from 1 to 4 carbon atoms), an alkanoyl, alkoxycarbonyl, alkoxycarbonylamino or alkylcarbamoyl group containing from 2 to 6 carbon atoms, or a hydroxy, formyl, nitro, trifluoromethyl, aryl, benzyloxycarbonylamino, amino, sulphamoyl, cyano, tetrazol-5-yl, carboxy, carbamoyl or aroyl group, and n represents an integer 1, 2 or 3, are new compounds possessing pharmacological properties, in particular properties of value in the treatment of respiratory disorders manifested by the interaction of tissue-fixed antibodies with specific antigens.