1448816-22-5

Basic information

• Product Name: (6-(2-hydroxy-4-methoxyphenyl)-1H-tetrazol-1-yl)-2,3,4-trimethoxyphenol
• Synonyms: (6-(2-hydroxy-4-methoxyphenyl)-1H-tetrazol-1-yl)-2,3,4-trimethoxyphenol
• CAS NO: 1448816-22-5
• Molecular Weight: 374.353
• Mol File: 1448816-22-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (6-(2-hydroxy-4-methoxyphenyl)-1H-tetrazol-1-yl)-2,3,4-trimethoxyphenol(CAS DataBase Reference)
• NIST Chemistry Reference: (6-(2-hydroxy-4-methoxyphenyl)-1H-tetrazol-1-yl)-2,3,4-trimethoxyphenol(1448816-22-5)
• EPA Substance Registry System: (6-(2-hydroxy-4-methoxyphenyl)-1H-tetrazol-1-yl)-2,3,4-trimethoxyphenol(1448816-22-5)

Safety Data

• Hazardous Substances Data: 1448816-22-5(Hazardous Substances Data)

Upstream product

• 1448816-31-6 2-(benzyloxy)-N-(2-(benzyloxy)-3,4,5-trimethoxyphenyl)-4-methoxybenzamide 
• 13618-49-0 2-(benzyloxy)-4-methoxybenzoic acid 
• 89-86-1 4-hydroxysalicylic acid 
• 13618-48-9 methyl-2-(benzyloxy)-4-methoxybenzoate 
• 52978-83-3 2,3,4-trimethoxy-6-nitrobenzaldehyde 
• 1448816-30-5 2-(benzyloxy)-3,4,5-trimethoxyaniline 
• 1448816-27-0 2-(benzyloxy)-3,4,5-trimethoxy-1-nitrobenzene 
• 5446-02-6 4-methoxymethylsalicylate 
• 142004-00-0 2-hydroxy-1-nitro-3,4,5-trimethoxybenzene 
• 2103-57-3 2,3,4-trimethoxybenzaldehyde 
• 1448816-36-1 1-(2-(benzyloxy)-3,4,5-trimethoxyphenyl)-5-(2-(benzyloxy)-4-methoxyphenyl)-1H-tetrazole 

Relevant articles and documents

Correlation of hydrogen-bonding propensity and anticancer profile of tetrazole-tethered combretastatin analogues

A series of 1,5-disubstituted tetrazole-tethered combretastatin analogues with extended hydrogen-bond donors at the ortho-positions of the aryl A and B rings were developed and evaluated for their antitubulin and antiproliferative activity. We wanted to test whether intramolecular hydrogen-bonding used as a conformational locking element in these analogues would improve their activity. The correlation of crystal structures with the antitubulin and antiproliferative profiles of the modified analogues suggested that hydrogen-bond-mediated conformational control of the A ring is deleterious to the bioactivity. In contrast, although there was no clear evidence that intramolecular hydrogen bonding to the B ring enhanced activity, we found that increased substitution on the B ring had a positive effect on antitubulin and antiproliferative activity. Among the various analogues synthesized, compounds 5d and 5e, having hydrogen-bonding donor groups at the ortho and meta-positions on the 4-methoxy phenyl B ring, are strong inhibitors of tubulin polymerization and antiproliferative agents having IC50 value in micromolar concentrations.