1365170-83-7

Basic information

• Product Name: C₂₄H₃₀N₈O₂
• Synonyms: C₂₄H₃₀N₈O₂
• CAS NO: 1365170-83-7
• Molecular Weight: 462.555
• Mol File: 1365170-83-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₄H₃₀N₈O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₄H₃₀N₈O₂(1365170-83-7)
• EPA Substance Registry System: C₂₄H₃₀N₈O₂(1365170-83-7)

Safety Data

• Hazardous Substances Data: 1365170-83-7(Hazardous Substances Data)

Upstream product

• 1365170-57-5 C₁₇H₁₈N₆O₂ 
• 29802-22-0 (S)-pyrrolidin-2-carboxylic acid dimethylamide 

Relevant articles and documents

Synthesis, SAR and biological evaluation of 1,6-disubstituted-1H- pyrazolo[3,4-d]pyrimidines as dual inhibitors of Aurora kinases and CDK1

Since the early 2000s, the Aurora kinases have become major targets of oncology drug discovery particularly Aurora-A and Aurora-B kinases (AKA/AKB) for which the selective inhibition in cells lead to different phenotypes. In addition to targeting these Aurora kinases involved in mitosis, CDK1 has been added as a primary inhibition target in hopes of enhancing the cytotoxicity of our chemotypes harboring the pyrazolopyrimidine core. SAR optimization of this series using the AKA, AKB and CDK1 biochemical assays led to the discovery of the compound 7h which combines strong potency against the 3 kinases with an acceptable microsomal stability. Finally, switching from a primary amide to a two-substituted pyrrolidine amide gave rise to compound 15a which exhibited the desired AKA/CDK1 inhibition phenotype in cells but showed moderate activity in animal models using HCT116 tumor cell lines.