29802-22-0

Basic information

• Product Name: H-PRO-NME2
• Synonyms: PROLINE-NME2;L-PYRROLIDINE-2-CARBOXYLIC ACID DIMETHYLAMIDE;L-PROLINE DIMETHYLAMIDE;H-PRO-NME2;H-PYRD(2)-NME2;L-PROLINE-N,N-DIMETHYLAMIDE;L-N,N,-DIMETHYL-PROLINAMIDE;N,N-Dimethylpyrrolidine-2-carboxamide
• CAS NO: 29802-22-0
• Molecular Formula: C₇H₁₄N₂O
• Molecular Weight: 142.2
• Product Categories: Proline [Pro, P];Amino Acids and Derivatives
• Mol File: 29802-22-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 250.2 °C at 760 mmHg
• Flash Point: 105.1 °C
• Appearance: /
• Density: 1.017 g/cm³
• Vapor Pressure: 0.0219mmHg at 25°C
• Refractive Index: 1.475
• Storage Temp.: -15°C
• PKA: 9.18±0.10(Predicted)
• CAS DataBase Reference: H-PRO-NME2(CAS DataBase Reference)
• NIST Chemistry Reference: H-PRO-NME2(29802-22-0)
• EPA Substance Registry System: H-PRO-NME2(29802-22-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26
• Hazardous Substances Data: 29802-22-0(Hazardous Substances Data)

Usage

Description

H-PRO-NME2, also known as L-Proline Dimethylamide, is a chemical compound that serves as a reactant in the synthesis of various pharmaceutical compounds. It is characterized by its unique molecular structure, which allows it to participate in the formation of complex molecules with potential therapeutic applications.

Uses

Used in Pharmaceutical Industry:
H-PRO-NME2 is used as a reactant for the synthesis of fluoromethylsulfonylaminophenyl propanamides, which are TRPV1 antagonists. These compounds have potential applications in the treatment of various conditions, such as pain, inflammation, and neurodegenerative diseases, due to their ability to block the TRPV1 receptor, which plays a role in sensory perception and cellular processes.

InChI:InChI=1/C7H14N2O/c1-9(2)7(10)6-4-3-5-8-6/h6,8H,3-5H2,1-2H3/t6-/m0/s1

Upstream product

• 42718-55-8 (S)-2-Dimethylcarbamoyl-pyrrolidine-1-carboxylic acid benzyl ester 
• 118916-60-2 (2R,5S)-2-trichloromethyl-1-aza-3-oxabicyclo[3.3.0]octan-4-one 
• 124-40-3 dimethyl amine 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 149152-54-5 tert-butyl (2S)-2-(dimethylcarbamoyl)pyrrolidine-1-carboxylate 
• 147-85-3 L-proline 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 

Downstream Products

• 609367-19-3 (S)-1-{(R)-2-[(Benzyloxy-formyl-amino)-methyl]-hexanoyl}-pyrrolidine-2-carboxylic acid dimethylamide 
• 1111659-06-3 (S)-N,N-dimethyl-1-(thiophen-2-ylmethyl)pyrrolidine-2-carboxamide 
• 151265-11-1 (S)-1-benzyl-N,N-dimethylpyrrolidine-2-carboxamide 
• 1111658-99-1 (S)-1-(4-tert-butylbenzyl)-N,N-dimethylpyrrolidine-2-carboxamide 
• 1111659-00-7 (S)-1-(4-bromobenzyl)-N,N-dimethylpyrrolidine-2-carboxamide 
• 1111659-03-0 (S)-N,N-dimethyl-1-(2-methylbenzyl)pyrrolidine-2-carboxamide 
• 1111659-01-8 (S)-N,N-dimethyl-1-(4-(trifluoromethyl)benzyl)pyrrolidine-2-carboxamide 
• 1365170-83-7 C₂₄H₃₀N₈O₂ 
• 26568-08-1 N-acetyl-(2S)-proline dimethyl amide 
• 1436436-11-1 N-thioacetyl-(2S)-proline dimethyl amide 

Relevant articles and documents

Basicities and Nucleophilicities of Pyrrolidines and Imidazolidinones Used as Organocatalysts

The Br?nsted basicities pKaH (i.e., pKa of the conjugate acids) of 32 pyrrolidines and imidazolidinones, commonly used in organocatalytic reactions, have been determined photometrically in acetonitrile solution using CH acids as indicators. Most investigated pyrrolidines have basicities in the range 16 aH aH aH 12.6) and the 2-imidazoliummethyl-substituted pyrrolidine A21 (pKaH 11.1) are outside the typical range for pyrrolidines with basicities comparable to those of imidazolidinones. Kinetics of the reactions of these 32 organocatalysts with benzhydrylium ions (Ar2CH+) and structurally related quinone methides, common reference electrophiles for quantifying nucleophilic reactivities, have been measured photometrically. Most reactions followed second-order kinetics, first order in amine and first order in electrophile. More complex kinetics were observed for the reactions of imidazolidinones and several pyrrolidines carrying bulky 2-substituents, due to reversibility of the initial attack of the amines at the electrophiles followed by rate-determining deprotonation of the intermediate ammonium ions. In the presence of 2,4,6-collidine or 2,6-di-tert-butyl-4-methyl-pyridine, the deprotonation of the initial adducts became faster, which allowed the rate of the attack of the amines at the electrophiles to be determined. The resulting second-order rate constants k2 followed the correlation log?k2(20 °C) = sN(N + E), where electrophiles are characterized by one parameter (E) and nucleophiles are characterized by the two solvent-dependent parameters N and sN. In this way, the organocatalysts A1-A32 were integrated in our comprehensive nucleophilicity scale, which compares n-, -, and σ-nucleophiles. The nucleophilic reactivities of the title compounds correlate only poorly with their Br?nsted basicities.

N →π* interactions of amides and thioamides: Implications for protein stability

Carbonyl-carbonyl interactions between adjacent backbone amides have been implicated in the conformational stability of proteins. By combining experimental and computational approaches, we show that relevant amidic carbonyl groups associate through an n→π

Structure-activity relationships of the peptide deformylase inhibitor BB-3497: Modification of the P2′ and P3′ side chains

Structural modifications to the peptide deformylase inhibitor BB-3497 are described. In this paper, we describe the initial SAR around this lead for modifications to both the P2′ and P3′ side chains. Enzyme inhibition and antibacterial activity data revealed that a variety of substituents are tolerated at the P2′ and P3′ positions of the inhibitor backbone. The data from this study highlights the potential for modification at the P2′ and P3′ positions to optimise the physicochemical properties.