136533-09-0

Basic information

• Product Name: N,N-dibenzyl-5-amino-3-oxapentan-1-ol
• Synonyms: N,N-dibenzyl-5-amino-3-oxapentan-1-ol
• CAS NO: 136533-09-0
• Molecular Weight: 285.386
• Mol File: 136533-09-0.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: N,N-dibenzyl-5-amino-3-oxapentan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-dibenzyl-5-amino-3-oxapentan-1-ol(136533-09-0)
• EPA Substance Registry System: N,N-dibenzyl-5-amino-3-oxapentan-1-ol(136533-09-0)

Safety Data

• Hazardous Substances Data: 136533-09-0(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 929-06-6 2-(2-Aminoethoxy)ethanol 

Downstream Products

• 1629676-61-4 3-(2-(2-(2-(dibenzylamino)ethoxy)ethoxy))tert-butyl propionate 
• 1356007-60-7 3β-{2-[2-(2-dibenzylamino)ethoxy]ethoxy}acetoxyolean-12-en-28-oic acid 
• 1349193-22-1 8-dibenzylamino-3,6-dioxaoctan-1-ol 
• 1301620-82-5 N₁,N₁-dibenzyl-N₉-octadecyl-3,6-dioxa-8-oxo-9-azaheptacosylamine 
• 166108-70-9 [2-(2-dibenzylaminoethoxy)ethoxy]acetic acid 

Relevant articles and documents

CROSS-LINKED PYRROLOBENZODIAZEPINE DIMER (PBD) DERIVATIVE AND ITS CONJUGATES

A novel cross-linked cytotoxic agents, pyrrolobenzo-diazepine dimer (PBD) derivatives, and their conjugates to a cell-binding molecule, a method for preparation of the conjugates and the therapeutic use of the conjugates.

A CONJUGATE OF A TUBULYSIN ANALOG WITH BRANCHED LINKERS

The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.

CONJUGATION OF A CYTOTOXIC DRUG WITH BIS-LINKAGE

What provided is the conjugation of cytotoxic to a cell-binding molecule with a bis-linker(dual-linker) as shown in Formula (I). It provides bis-linkage methods of making a conjugate of a cytotoxic drug molecule to a cell-binding agent in a specific manner. It also relates to application of the conjugates for the treatment of a cancer, or an autoimmune disease, or an infectious disease.