13672-24-7

Basic information

• Product Name: Acetic acid, [1,2-dihydro-2-oxo-1-(phenylmethyl)-3H-indol-3-ylidene]-, ethyl ester, (E)-
• CAS NO: 13672-24-7
• Molecular Formula: C19H17NO3
• Molecular Weight: 307.349
• Mol File: 13672-24-7.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Acetic acid, [1,2-dihydro-2-oxo-1-(phenylmethyl)-3H-indol-3-ylidene]-, ethyl ester, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, [1,2-dihydro-2-oxo-1-(phenylmethyl)-3H-indol-3-ylidene]-, ethyl ester, (E)-(13672-24-7)
• EPA Substance Registry System: Acetic acid, [1,2-dihydro-2-oxo-1-(phenylmethyl)-3H-indol-3-ylidene]-, ethyl ester, (E)-(13672-24-7)

Safety Data

• Hazardous Substances Data: 13672-24-7(Hazardous Substances Data)

Upstream product

• 924-44-7 glyoxylic acid ethyl ester 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 2999-46-4 Ethyl isocyanoacetate 
• 1217-89-6 1-benzylisatin 
• 615-43-0 2-iodophenylamine 
• 139115-67-6 ethyl (E)-4--4-oxobut-2-enoate 
• 2459-05-4 (E)-4-ethoxy-4-oxobut-2-enoic acid 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 100-39-0 benzyl bromide 
• 91-56-5 indole-2,3-dione 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 

Downstream Products

• 13672-25-8 ethyl 2-(1-benzyl-2-oxoindolin-3-yl)acetate 
• 1345838-24-5 (2'S,3'R)-ethyl 1-benzyl-2-oxospiro[indoline-3,2'-oxirane]-3'-carboxylate 
• 1345838-23-4 (2'R,3'R)-ethyl 1-benzyl-2-oxospiro[indoline-3,2'-oxirane]-3'-carboxylate 

Relevant articles and documents

Divergent Synthesis of Oxindolylidene Acetates and Spirooxindolopyrrolidones from Arynes

A novel process for the preparation of various (E)-oxindolylidene acetates using arynes and carbamoylpropiolates has been developed. The utility of this protocol is also further extended to the one-pot synthesis of complex spirooxindolopyrrolidones. This method provides a milder and transition-metal-free access to both of the target scaffolds in moderate to good yields.

When Ethyl Isocyanoacetate Meets Isatins: A 1,3-Dipolar/Inverse 1,3-Dipolar/Olefination Reaction for Access to 3-Ylideneoxindoles

A new CuI/1,10-phen-catalyzed reaction for the synthesis of 3-ylideneoxindoles from readily available isatins and ethyl isocyanoacetate, in which ethyl isocyanoacetate acts as a latent two-carbon donor like the Wittig reagent, is reported. A tandem procedure including 1,3-dipolar cycloaddition/inverse 1,3-dipolar ring opening/olefination allows the preparation of 3-ylideneoxindoles with broad functional group tolerance.

Construction of 1-pyrroline skeletons by Lewis acid-mediated conjugate addition of vinyl azides

Lewis acid-mediated conjugate addition of vinyl azides to electron-deficient alkenes led to the efficient construction of 1-pyrroline skeletons. The reactions of vinyl azides with 3-alkylidene-2-oxoindolines afford 3′,4′-dihydrospiro[indoline-3,2′-pyrrol]-2-ones in a diastereoselective fashion, whereas those with dimethyl 2-alkylidenemalonates provide 4,5-dihydro-3H-pyrroles.