1372658-92-8Relevant articles and documents
Convenient synthesis of Nε-(carboxymethyl)lysine, a key advanced glycation endproduct biomarker
Andersen, Jeanette M.,Hjelmgaard, Thomas,Dragsted, Lars O.,Nielsen, John
, p. 531 - 534 (2012)
Advanced glycation endproducts (AGEs) are formed when sugars react with peptides and proteins without the help of enzymes and by thermal processing of food such as baking and frying. AGEs and especially N-(carboxymethyl) lysine (CML) has been used as general key biomarkers for oxidative stress and a number of diseases associated with poor lifestyle. Herein we present the first synthetic pathway to the free zwitter ion of CML via a protected intermediate. Georg Thieme Verlag Stuttgart · New York.