1375180-28-1

Basic information

• Product Name: 1-[3-(benzyloxy)propyl]-7-bromoindoline-5-carbaldehyde
• Synonyms: 1-[3-(benzyloxy)propyl]-7-bromoindoline-5-carbaldehyde
• CAS NO: 1375180-28-1
• Molecular Weight: 374.277
• Mol File: 1375180-28-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-[3-(benzyloxy)propyl]-7-bromoindoline-5-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[3-(benzyloxy)propyl]-7-bromoindoline-5-carbaldehyde(1375180-28-1)
• EPA Substance Registry System: 1-[3-(benzyloxy)propyl]-7-bromoindoline-5-carbaldehyde(1375180-28-1)

Safety Data

• Hazardous Substances Data: 1375180-28-1(Hazardous Substances Data)

Upstream product

• 496-15-1 1-indoline 
• 459868-64-5 1-[3-(benzyloxy)propyl]indoline 
• 459868-63-4 1-[3-(benzyloxy)propyl]indoline-5-carbaldehyde 
• 26420-79-1 1-chloro-3-benzyloxypropane 
• 100-39-0 benzyl bromide 

Downstream Products

• 1375180-30-5 1-[3-(benzyloxy)propyl]-5-formylindoline-7-carbonitrile 
• 160970-54-7 silodosin 
• 459868-77-0 2,3-dihydro-1-[3-(phenylmethoxy)propyl]-5-[(2R)-2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]-1H-indole-7-carbonitrile 
• 1096141-50-2 1-[3-(benzyloxy)propyl]-2,3-dihydro-5-(2-oxopropyl)-1H-indole-7-carbonitrile 
• 1374461-77-4 1-[3-(benzyloxy)propyl]-5-(2-nitroprop-1-en-1-yl)indoline-7-carbonitrile 
• 175870-40-3 1-[3-(benzyloxy)propyl]-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)-phenoxy]ethyl}amino)propyl]indoline-7-carboxamide 
• 1374461-73-0 1-[3-(benzyloxy)propyl]-5-[(2R)-2-([(1R)-1-phenylethyl]{2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]indoline-7-carbonitrile 
• 1374461-74-1 1-[3-(benzyloxy)propyl]-5-[(2R)-2-{[(1R)-1-phenylethyl]amino}propyl]indoline-7-carbonitrile 
• 1423218-38-5 C₂₄H₂₈BrNO₃ 
• 900518-68-5 C₃₀H₃₃N₃O₃ 
• 1423218-40-9 tert-butyl (2R)-(1-(1-(3-benzyloxypropyl)-7-cyanoindolin-5-yl)propane-2-yl)-N-(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)carbamate 
• 175870-34-5 tert-butyl (2R)-(1-(1-(3-benzyloxypropyl)-7-carbamoylindolin-5-yl)propan-2-yl)-N-(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)carbamate 
• 459868-73-6 C₂₂H₂₇N₃O 
• 1423218-39-6 (E)-3-(1-(3-(benzyloxy)propyl)-7-bromoindolin-5-yl)-2-methylacrylic acid 

Relevant articles and documents

Silodosin Intermediate and Preparation Method Therefor

Disclosed are a silodosin intermediate and a preparation method thereof. The silodosin intermediate has the structure shown by the formula (A). X is hydrogen or bromide and R1 is hydrogen. The formyl group may be a group having the structure sh

A METHOD OF MANUFACTURING (-)-L-(3-HYDROXYPROPYL)-5-[(2R)-2-({2,2,2-TRIFLUOROETHOXY)- PHENOXYETHYL}AMINO)PROPYL]-2,3-DIHYDRO-LH-INDOLE-7-CARBOXAMIDE

A method of manufacturing optically pure or optically enriched silodosin of formula I and of its pharmaceutically acceptable salts, in which a secondary amine of general formula II, wherein Bn denotes a phenylmethyl group, substituted or unsubstituted in the benzene ring, e.g. benzyl or 4-methoxybenzyl, or the benzhydryl or trityl group, (a) is N-alkylated with an alkylating agent of general formula III, wherein X denotes a good leaving group, such as a halogen or an alkane sulfonyloxyl group RS020 or an arene SLilfonyloxyl group ArS020, R means an alkyl group with 1 to 4 carbon atoms and Ar is a substituted or unsubstituted phenyl group; (b) the obtained tertiary amine of general formula IV, wherein Bn is as defined above, is hydrogenolyzed with hydrogen on a metal catalyst; (c) and the resulting nitrile of formula V, wherein Bn is as defined above, is hydrolyzed by treatment with alkaline agents; and optionally, (d) additional O-debenzylation of the amide-ether of general formula VI, wherein Bn is as defined above, with dealkylating agents is carried out; and, if desired, the obtained silodosin is transformed to the respective salts by treatment with pharmaceutically acceptable acids.