459868-77-0

Basic information

• Product Name: 2,3-DIHYDRO-1-[3-(PHENYLMETHOXY)PROPYL]-5-[(2R)-2-[[2-[2[(2,2,2-TRIFLUOROETHOXY)PHENOXY]ETHYL] AMINO]PROPYL]-1H-INDOLE-7-CARBONITRILE
• Synonyms: 2,3-DIHYDRO-1-[3-(PHENYLMETHOXY)PROPYL]-5-[(2R)-2-[[2-[2[(2,2,2-TRIFLUOROETHOXY)PHENOXY]ETHYL] AMINO]PROPYL]-1H-INDOLE-7-CARBONITRILE
• CAS NO: 459868-77-0
• Molecular Weight: 567.651
• Mol File: 459868-77-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2,3-DIHYDRO-1-[3-(PHENYLMETHOXY)PROPYL]-5-[(2R)-2-[[2-[2[(2,2,2-TRIFLUOROETHOXY)PHENOXY]ETHYL] AMINO]PROPYL]-1H-INDOLE-7-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIHYDRO-1-[3-(PHENYLMETHOXY)PROPYL]-5-[(2R)-2-[[2-[2[(2,2,2-TRIFLUOROETHOXY)PHENOXY]ETHYL] AMINO]PROPYL]-1H-INDOLE-7-CARBONITRILE(459868-77-0)
• EPA Substance Registry System: 2,3-DIHYDRO-1-[3-(PHENYLMETHOXY)PROPYL]-5-[(2R)-2-[[2-[2[(2,2,2-TRIFLUOROETHOXY)PHENOXY]ETHYL] AMINO]PROPYL]-1H-INDOLE-7-CARBONITRILE(459868-77-0)

Safety Data

• Hazardous Substances Data: 459868-77-0(Hazardous Substances Data)

Upstream product

• 900518-67-4 C₂₉H₃₃BrN₂O₃ 
• 1394258-01-5 C₂₂H₂₆BrNO₃ 
• 1423218-39-6 (E)-3-(1-(3-(benzyloxy)propyl)-7-bromoindolin-5-yl)-2-methylacrylic acid 
• 1423218-38-5 C₂₄H₂₈BrNO₃ 
• 496-15-1 1-indoline 
• 459868-73-6 C₂₂H₂₇N₃O 
• 459868-80-5 2-[2-(2,2,2-trifluoroethoxy)-phenoxy]ethyl 4-methylbenzenesulfonate 
• 900518-68-5 C₃₀H₃₃N₃O₃ 
• 1374461-74-1 1-[3-(benzyloxy)propyl]-5-[(2R)-2-{[(1R)-1-phenylethyl]amino}propyl]indoline-7-carbonitrile 
• 1374461-73-0 1-[3-(benzyloxy)propyl]-5-[(2R)-2-([(1R)-1-phenylethyl]{2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]indoline-7-carbonitrile 
• 459868-64-5 1-[3-(benzyloxy)propyl]indoline 
• 1375180-30-5 1-[3-(benzyloxy)propyl]-5-formylindoline-7-carbonitrile 
• 459868-63-4 1-[3-(benzyloxy)propyl]indoline-5-carbaldehyde 
• 1375180-28-1 1-[3-(benzyloxy)propyl]-7-bromoindoline-5-carbaldehyde 

Downstream Products

• 160970-54-7 silodosin 
• 175870-40-3 1-[3-(benzyloxy)propyl]-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)-phenoxy]ethyl}amino)propyl]indoline-7-carboxamide 
• 175870-34-5 tert-butyl (2R)-(1-(1-(3-benzyloxypropyl)-7-carbamoylindolin-5-yl)propan-2-yl)-N-(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)carbamate 
• 1423218-40-9 tert-butyl (2R)-(1-(1-(3-benzyloxypropyl)-7-cyanoindolin-5-yl)propane-2-yl)-N-(2-(2-(2,2,2-trifluoroethoxy)phenoxy)ethyl)carbamate 

Relevant articles and documents

First asymmetric synthesis of Silodosin through catalytic hydrogenation by using Ir-SIPHOX catalysts

An asymmetric synthesis of Silodosin was accomplished in high yield via catalytic hydrogenation of α,β-unsaturated carboxylic acid derivatives by using chiral catalyst Ir-SIPHOX, followed by Curtius rearrangement. Copyright

METHOD FOR PRODUCING OPTICALLY ACTIVE AMINE

The present invention provides a method for producing chiral amines, comprising asymmetric transfer hydrogenation of imine compounds in the presence of a hydrogen donor compound and an iridium(III) complex having a chiral prolinamide compound as a ligand. The present invention is useful for production of chiral amines in an efficient manner in terms of their optical and chemical yields.