1378834-16-2

Basic information

• Product Name: 6′-fluoro-1′,2′-dihydrospiro[cyclopropane-1,3′-indole]-2′-one
• CAS NO: 1378834-16-2
• Molecular Weight: 177.178
• Mol File: 1378834-16-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 6′-fluoro-1′,2′-dihydrospiro[cyclopropane-1,3′-indole]-2′-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6′-fluoro-1′,2′-dihydrospiro[cyclopropane-1,3′-indole]-2′-one(1378834-16-2)
• EPA Substance Registry System: 6′-fluoro-1′,2′-dihydrospiro[cyclopropane-1,3′-indole]-2′-one(1378834-16-2)

Safety Data

• Hazardous Substances Data: 1378834-16-2(Hazardous Substances Data)

Upstream product

• 56341-39-0 6-fluoro-2-oxindole 
• 247129-85-7 (2-bromoethyl)(diphenyl)sulfonium trifluoromethanesulfonate 
• 1209007-72-6 ethyl 2-(4-fluoro-2-nitrophenyl)acetate 
• 364-74-9 1,4-difluoro-2-nitrobenzene 
• 106-93-4 ethylene dibromide 

Relevant articles and documents

Zinc triflate-mediated cyclopropanation of oxindoles with vinyl diphenyl sulfonium triflate: a mild reaction with broad functional group compatibility

The first use of zinc triflate for the cyclopropanation of unprotected oxindoles with vinyl diphenyl sulfonium triflate salt is reported. The reaction proceeded under ambient conditions and consistently provided high yields with broad functional group tolerability. The utility for the late-stage functionalization (LSF) of complex molecules is demonstrated.

A convenient cyclopropanation process of oxindoles via bromoethylsulfonium salt

A practical convenient conversion of oxindoles into the corresponding spirocyclopropyl oxindoles is achieved efficiently using bromoethylsulfonium salt, which is easily prepared on a large scale and is stable crystalline. This reaction of bromoethylsulfonium salt with different substituted unprotected oxindoles proceeded under mild condition and provided moderate yields.

TRICYCLIC SULFONAMIDE DERIVATIVES

The invention relates to derivatives of formula (I), wherein the substituents are as defined in the specification; to processes for the preparation of such derivatives; pharmaceutical compositions comprising such derivatives; such derivatives as a medicament; such derivatives for the treatment of pain.