56341-39-0

Basic information

• Product Name: 6-Fluoro-2-oxindole
• Synonyms: 6-FLUOROOXINDOLE;BUTTPARK 24\07-31;6-Fluoro-2-oxoindole;6-Fluorooxindole 97%;6-Fluorooxindole97%;2H-Indol-2-one,6-fluoro-1,3-dihydro-(9CI);6-Fluoro-2-oxindole;6-Fluoro-1,3-dihydro-2H-indol-2-one
• CAS NO: 56341-39-0
• Molecular Formula: C₈H₆FNO
• Molecular Weight: 151.14
• EINECS: 1312995-182-4
• Product Categories: INDOLE;blocks;FluoroCompounds;IndolesOxindoles;Indole/indoline/oxindole;Indole and Indoline;Indoles
• Mol File: 56341-39-0.mol
• Article Data: 22

Chemical Properties

• Melting Point: 132-136°C
• Boiling Point: 287.5 °C at 760 mmHg
• Flash Point: 127.6 °C
• Appearance: /
• Density: 1.311 g/cm³
• Vapor Pressure: 0.00248mmHg at 25°C
• Refractive Index: 1.56
• Storage Temp.: Keep Cold
• PKA: 13.37±0.20(Predicted)
• CAS DataBase Reference: 6-Fluoro-2-oxindole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Fluoro-2-oxindole(56341-39-0)
• EPA Substance Registry System: 6-Fluoro-2-oxindole(56341-39-0)

Safety Data

• Hazard Codes: Xi,C,Xn
• Statements: 36/37/38-34-22
• Safety Statements: 26-36/37/39-45-27
• Hazardous Substances Data: 56341-39-0(Hazardous Substances Data)

Usage

General Description

6-Fluoro-2-oxindole is a chemical compound with the molecular formula C8H6FNO. Derived from indole, it’s a part of the bioactive heterocyclic compound family. Introducing a fluorine atom to an organic compound can greatly affect its reactivity and the properties of the whole molecule. Its introduction in 6-fluoro-2-oxindole can improve the compound's metabolic stability, bioavailability, and enhance its ability to permeate cell membranes. It can be prepared under conventional heating conditions. However, it should be handled carefully because of the limited available information about its hazardous properties. This chemical has been used in various research and scientific applications, especially in organic synthesis, drug discovery, and medicinal chemistry.

InChI:InChI=1/C8H6FNO/c9-6-2-1-5-3-8(11)10-7(5)4-6/h1-2,4H,3H2,(H,10,11)

Upstream product

• 147124-38-7 methyl (4-fluoro-2-nitrophenyl)acetate 
• 39616-95-0 2-(4-fluoro-2-nitrophenyl)acetic acid 
• 147124-35-4 dimethyl 2-(4-fluoro-2-nitrophenyl)malonate 
• 364-74-9 1,4-difluoro-2-nitrobenzene 
• 350-81-2 2-chloro-N-(3-fluorophenyl)acetamide 
• 372-19-0 meta-fluoroaniline 
• 1209007-72-6 ethyl 2-(4-fluoro-2-nitrophenyl)acetate 
• 399-51-9 6-fluoro-1H-indole 
• 324-03-8 6-fluoroisatin 

Downstream Products

• 1378834-16-2 6′-fluoro-1′,2′-dihydrospiro[cyclopropane-1,3′-indole]-2′-one 
• 1421506-54-8 (E)-6-fluoro-3-(4-trifluoromethyl-benzylidene)-1,3-dihydro-indol-2-one 
• 1421506-53-7 (E)-6-fluoro-3-(2-trifluoromethyl-benzylidene)-1,3-dihydro-indol-2-one 
• 1421506-56-0 (E)-6-fluoro-3-(3-trifluoromethoxyl-benzylidene)-1,3-dihydro-indol-2-one 
• 1421506-57-1 (E)-6-fluoro-3-(3-methanesulfonyl-benzylidene)-1,3-dihydro-indol-2-one 
• 1421506-49-1 (E)-6-fluoro-3-(4-fluoro-benzylidene)-1,3-dihydro-indol-2-one 
• 1421506-47-9 (E)-6-fluoro-3-(3-fluoro-benzylidene)-1,3-dihydro-indol-2-one 
• 1421506-46-8 (E)-6-fluoro-3-(2-fluoro-benzylidene)-1,3-dihydro-indol-2-one 
• 1148119-16-7 (E)-6-fluoro-3-(3-trifluoromethyl-benzylidene)-1,3-dihydro-indol-2-one 

Relevant articles and documents

A novel methodology for the efficient synthesis of 3-monohalooxindoles by acidolysis of 3-phosphate-substituted oxindoles with haloid acids

A novel method for the synthesis of 3-monohalooxindoles by acidolysis of isatin-derived 3-phosphate-substituted oxindoles with haloid acids was developed. This synthetic strategy involved the preparation of 3-phosphate-substituted oxindole intermediates and SN1 reactions with haloid acids. This new procedure features mild reaction conditions, simple operation, good yield, readily available and inexpensive starting materials, and gram-scalability.

SPIRO-INDOLINES FOR THE TREATMENT AND PROPHYLAXIS OF RESPIRATORY SYNCYTIAL VIRUS INFECTION (RSV)

Benzimidazoles of formula (I): wherein: one of X and Y is an N atom or a substituted C atom, and the other is CH; L is a single bond, C1-3 alkylene, C2-3 alkenylene or C2-3 alkynylene; R1 is C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, 3- to 10-membered cycloalkyl, 5- to 10-membered heterocyclyl or 5- to 12- membered heteroaryl, each of which is unsubstituted or substituted; Z is halo, C1-6 haloalkyl, nitro, -CN, -N(R2)2, -OR2, -SR2, -S(=0)R2, or -S(=0)2R2; each R2 is independently hydrogen, C1-6 alkyl, C2-6 alkenyl or C2-6 alkynyl, wherein said alkyl, alkenyl and alkynyl groups are unsubstituted or substituted; and m is 0 or 1; and the pharmaceutically acceptable salt thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.

OLEFIN SUBSTITUTED OXINDOLES HAVING AMPK ACTIVITY

The present invention relates to compounds of formula (I), which have valuable pharmacological properties, in particular are activators of AMPK and which are therefore useful in the treatment of certain disorders that can be prevented or treated by activation of this receptor. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.