147124-35-4

Basic information

• Product Name: Propanedioic acid, (4-fluoro-2-nitrophenyl)-, dimethyl ester
• CAS NO: 147124-35-4
• Molecular Formula: C11H10FNO6
• Molecular Weight: 271.202
• Mol File: 147124-35-4.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, (4-fluoro-2-nitrophenyl)-, dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, (4-fluoro-2-nitrophenyl)-, dimethyl ester(147124-35-4)
• EPA Substance Registry System: Propanedioic acid, (4-fluoro-2-nitrophenyl)-, dimethyl ester(147124-35-4)

Safety Data

• Hazardous Substances Data: 147124-35-4(Hazardous Substances Data)

Upstream product

• 108-59-8 malonic acid dimethyl ester 
• 364-74-9 1,4-difluoro-2-nitrobenzene 
• 299914-24-2 4-[3-(2-nitro-phenoxy)-propyl]-morpholine 

Downstream Products

• 56341-39-0 6-fluoro-2-oxindole 
• 39616-95-0 2-(4-fluoro-2-nitrophenyl)acetic acid 
• 147124-38-7 methyl (4-fluoro-2-nitrophenyl)acetate 

Relevant articles and documents

A Unified Catalytic Asymmetric (4+1) and (5+1) Annulation Strategy to Access Chiral Spirooxindole-Fused Oxacycles

A unified catalytic asymmetric (N+1) (N=4, 5) annulation reaction of oxindoles with bifunctional peroxides has been achieved in the presence of a chiral phase-transfer catalyst (PTC). This general strategy utilizes peroxides as unique bielectrophilic four- or five-atom synthons to participate in the C?C and the subsequent umpolung C?O bond-forming reactions with one-carbon unit nucleophiles, thus providing a distinct method to access the valuable chiral spirooxindole-tetrahydrofurans and -tetrahydropyrans with good yields and high enantioselectivities under mild conditions. DFT calculations were performed to rationalize the origin of high enantioselectivity. The gram-scale syntheses and synthetic utility of the resultant products were also demonstrated.

Phenylaminopropanol derivatives and methods of their use

The present invention is directed to phenylaminopropanol derivatives of formulae I, II, and III: [image] or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms (VMS), sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromyalgia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, schizophrenia, and combinations thereof.

Concise syntheses of the cruciferous phytoalexins brassilexin, sinalexin, wasalexins, and analogues: Expanding the scope of the Vilsmeier formylation

(Chemical Equation Presented) Efficient syntheses of the phytoalexins brassilexin, sinalexin, and analogues are demonstrated through the application of the Vilsmeier formylation to indoline-2-thiones followed by a new aqueous ammonia workup procedure. Similarly, a very concise two-pot synthesis of the phytoalexins wasalexins using sequential formylation-amination of indolin-2-ones is described. Remarkably, this novel aqueous ammonia workup allows the sequential one-pot formylation-amination, expanding substantially the scope of the Vilsmeier formylation of both indoline-2-thiones and indolin-2-ones. The examination of the formylation-amination reaction and optimization of conditions, as well as the syntheses and antifungal activities of several brassilexin analogues, are reported.