1381781-05-0

Basic information

• Product Name: C₂₂H₃₀Br₂O₄
• Synonyms: C₂₂H₃₀Br₂O₄
• CAS NO: 1381781-05-0
• Molecular Weight: 518.286
• Mol File: 1381781-05-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₃₀Br₂O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₃₀Br₂O₄(1381781-05-0)
• EPA Substance Registry System: C₂₂H₃₀Br₂O₄(1381781-05-0)

Safety Data

• Hazardous Substances Data: 1381781-05-0(Hazardous Substances Data)

Upstream product

• 252679-37-1 4-((2E)-3,7-dimethyl-2,6-octadienyl)-3,5-bis(methoxymethoxy)benzyl alcohol 
• 76280-59-6 methyl 3,5-bis(methoxymethoxy)benzoate 
• 495412-19-6 4-(3,7-dimethyl-octa-2,6-dienyl)-3,5-bis-methoxymethoxy-benzaldehyde 
• 558-13-4 carbon tetrabromide 

Downstream Products

• 1151549-93-7 C₂₅H₃₀O₃ 
• 1151549-99-3 C₂₅H₂₇F₃O₂ 
• 1381781-07-2 C₂₅H₂₇F₃O₂ 
• 1151549-96-0 C₂₄H₂₇FO₂ 
• 1381781-09-4 C₂₄H₂₆F₂O₂ 
• 1381781-10-7 C₂₄H₂₇ClO₂ 
• 1381781-11-8 C₂₅H₂₈O₃ 
• 1381781-12-9 C₂₂H₂₆O₃ 
• 1381781-06-1 C₂₂H₃₁BrO₄ 
• 72165-33-4 Amorphastilbol 
• 117047-35-5 4-geranyl-3,5,4'-trihydroxy-trans-stilbene 

Relevant articles and documents

Total synthesis and dual PPARα/γ agonist effects of Amorphastilbol and its synthetic derivatives

Amorphastilbol (APH-1), isolated from a Robinia pseudoacacia var. umbraculifer seed extract, is a biologically interesting natural trans-stilbene compound with dual peroxisome proliferator-activated receptor (PPAR) α/γ agonist activity. After total synthesis of APH-1 and its derivatives by Pd-catalyzed Suzuki-Miyaura cross-coupling of a common (E)-styryl bromide intermediate and various aromatic trifluoroborate compounds, we biologically evaluated APH-2-APH-12 for PPAR agonist activity. APH-4 and APH-11 were effective PPARα/γ transcriptional activators, compared with APH-1. Therefore, we suggest that APH-4 and APH-11 are novel dual PPARα/γ agonists and are potentially useful for treating type 2 diabetes by enhancing glucose and lipid metabolism.