495412-19-6

Basic information

• Product Name: Benzaldehyde, 4-[(2E)-3,7-dimethyl-2,6-octadienyl]-3,5-bis(methoxymethoxy)-
• CAS NO: 495412-19-6
• Molecular Formula: C21H30O5
• Molecular Weight: 362.466
• Mol File: 495412-19-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 4-[(2E)-3,7-dimethyl-2,6-octadienyl]-3,5-bis(methoxymethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 4-[(2E)-3,7-dimethyl-2,6-octadienyl]-3,5-bis(methoxymethoxy)-(495412-19-6)
• EPA Substance Registry System: Benzaldehyde, 4-[(2E)-3,7-dimethyl-2,6-octadienyl]-3,5-bis(methoxymethoxy)-(495412-19-6)

Safety Data

• Hazardous Substances Data: 495412-19-6(Hazardous Substances Data)

Upstream product

• 144337-52-0 3,5-bis(methoxymethoxy)-1-<<(tert-butyldimethylsilyl)oxy>methyl>benzene 
• 76280-60-9 [3,5-bis(methoxymethoxy)phenyl]methanol 
• 2150-44-9 1-carbomethoxy-3,5-dihydroxybenzene 
• 252679-37-1 4-((2E)-3,7-dimethyl-2,6-octadienyl)-3,5-bis(methoxymethoxy)benzyl alcohol 

Downstream Products

• 1069118-65-5 C₄₂H₆₀O₉ 
• 1069118-62-2 (2R,4aR,9aR)-2,5',7'-O-tri(methoxymethyl)-3-deoxyschweinfurthin B 
• 1381781-06-1 C₂₂H₃₁BrO₄ 
• 72165-33-4 Amorphastilbol 
• 117047-35-5 4-geranyl-3,5,4'-trihydroxy-trans-stilbene 
• 1381781-05-0 C₂₂H₃₀Br₂O₄ 

Relevant articles and documents

Total synthesis and dual PPARα/γ agonist effects of Amorphastilbol and its synthetic derivatives

Amorphastilbol (APH-1), isolated from a Robinia pseudoacacia var. umbraculifer seed extract, is a biologically interesting natural trans-stilbene compound with dual peroxisome proliferator-activated receptor (PPAR) α/γ agonist activity. After total synthesis of APH-1 and its derivatives by Pd-catalyzed Suzuki-Miyaura cross-coupling of a common (E)-styryl bromide intermediate and various aromatic trifluoroborate compounds, we biologically evaluated APH-2-APH-12 for PPAR agonist activity. APH-4 and APH-11 were effective PPARα/γ transcriptional activators, compared with APH-1. Therefore, we suggest that APH-4 and APH-11 are novel dual PPARα/γ agonists and are potentially useful for treating type 2 diabetes by enhancing glucose and lipid metabolism.

Cytoprotective compounds, pharmaceutical and cosmetic formulations, and methods

Cytoprotective compounds, many of which are phenolic derivatives characterized by a substituted phenol having certain conjugated bonds, are useful in the treatment of certain ischemic or inflammatory conditions, including but not limited to stroke, myocardial infarction, congestive heart failure, and skin disorders characterized by inflammation or oxidative damage. They are also useful in the manufacture of pharmaceutical and cosmetic formulations for the treatment of such conditions.