138227-62-0

Basic information

• Product Name: 1N-BOC 4-(4'-NITROPHENOXY) PIPERIDINE
• Synonyms: TERT-BUTYL 4-(4-NITROPHENOXY)PIPERIDINE-1-CARBOXYLATE;TERT-BUTYL 4-(4-NITROPHENOXY)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE;BUTTPARK 99\57-88;1N-BOC 4-(4'-NITROPHENOXY) PIPERIDINE;4-(4-NITROPHENOXY)PIPERIDINE, N-BOC PROTECTED;1N-Boc 4-(4'-nitrophenyl) piperidine;4-(4-Nitrophenoxy)piperidine, N-BOC protected 97%;1-Boc-4-(4'-Nitrophenoxy)piperidine
• CAS NO: 138227-62-0
• Molecular Formula: C₁₆H₂₂N₂O₅
• Molecular Weight: 322.36
• EINECS: 604-604-1
• Mol File: 138227-62-0.mol
• Article Data: 34

Chemical Properties

• Melting Point: 99 °C
• Boiling Point: 453.7 °C at 760 mmHg
• Flash Point: 228.2 °C
• Appearance: /
• Density: 1.211 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1N-BOC 4-(4'-NITROPHENOXY) PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1N-BOC 4-(4'-NITROPHENOXY) PIPERIDINE(138227-62-0)
• EPA Substance Registry System: 1N-BOC 4-(4'-NITROPHENOXY) PIPERIDINE(138227-62-0)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 138227-62-0(Hazardous Substances Data)

Usage

General Description

1N-BOC 4-(4'-nitrophenoxy) piperidine is a chemical compound that belongs to the class of piperidine derivatives. It is a piperidine derivative that contains a Boc-protected amino group and a 4-(4'-nitrophenoxy) substituent. It is often used as a building block in the synthesis of various pharmaceuticals and organic compounds. 1N-BOC 4-(4'-NITROPHENOXY) PIPERIDINE has the potential to be used in medicinal chemistry and drug development due to its unique structure and biological properties. Its Boc-protected amino group allows for easy manipulation and modification, making it a valuable tool for chemical synthesis and drug discovery.

Upstream product

• 350-46-9 4-Fluoronitrobenzene 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 100-02-7 4-nitro-phenol 
• 1972-28-7 diethylazodicarboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 118811-07-7 tert-butyl 4-(tosyloxy)piperidin-1-carboxylate 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 138227-58-4 1-Acetyl-4-(4-nitrophenyloxy)-piperidine 
• 141-78-6 ethyl acetate 

Downstream Products

• 138227-63-1 tert-butyl 4-(4-aminophenoxy)piperidine-1-carboxylate 
• 1566585-23-6 tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-methylpyrimidin-2-yl)amino)phenoxy)piperidine-1-carboxylate 
• 1566584-08-4 2-(2-(2-(5-methyl-2-((4-(piperidin-4-yloxy)phenyl)amino)pyrimidin-4-yl)ethyl)phenyl)acetamide 
• 1637586-79-8 1-ethyl-3-(4-((1-(3-fluoro-4-(trifluoromethyl)benzoyl)piperidin-4-yl)oxy)phenyl)urea 
• 1637586-80-1 1-(2-chloroethyl)-3-(4-((1-(3-fluoro-4-(trifluoromethyl)benzoyl)piperidin-4-yl)oxy)phenyl)urea 
• 1637586-81-2 1-(4-((1-(3-fluoro-4-(trifluoromethyl)benzoyl)piperidin-4-yl)oxy)phenyl)imidazolidin-2-one 
• 1637586-82-3 1-ethyl-3-(4-((1-((4-fluorophenyl)sulfonyl)piperidin-4-yl)oxy)phenyl)urea 
• 1637586-77-6 (4-(4-aminophenoxy)piperidin-1-yl)(3-fluoro-4-(trifluoromethyl)phenyl)methanone 
• 1637586-78-7 4-((1-((4-fluorophenyl)sulfonyl)piperidin-4-yl)oxy)aniline 
• 1637586-75-4 C₁₉H₁₆F₄N₂O₄ 
• 1637586-76-5 C₁₇H₁₇FN₂O₅S 
• 862310-27-8 1-cyclopentyl -4-(4-nitrophenoxy)piperidine 
• 862310-29-0 4-((1-cyclopentylpiperidin-4-yl)oxy)aniline 
• 1085842-35-8 4-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenoxy}-piperidine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Straightforward synthesis of a novel ring-fused pyrazole-lactam and in vitro cytotoxic activity on cancer cell lines

In this paper a straightforward synthesis of a novel pyrazole derivative is reported. Prominent feature of this synthetic process is a 1,3-Dipolar Cycloaddition of a suitable nitrile imine with an activated α,β-unsaturated lactam to afford directly and re

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Discovery and Development of N-[4-(1-Cyclobutylpiperidin-4-yloxy)phenyl]-2-(morpholin-4-yl)acetamide Dihydrochloride (SUVN-G3031): A Novel, Potent, Selective, and Orally Active Histamine H3 Receptor Inverse Agonist with Robust Wake-Promoting Activity

A series of chemical optimizations guided by in vitro affinity at a histamine H3 receptor (H3R), physicochemical properties, and pharmacokinetics in rats resulted in identification of N-[4-(1-cyclobutyl-piperidin-4-yloxy)phenyl]-2-(morpholin-4-yl)acetamide dihydrochloride (17v, SUVN-G3031) as a clinical candidate. Compound 17v is a potent (hH3R Ki = 8.73 nM) inverse agonist at H3R with selectivity over other 70 targets, Compound 17v has adequate oral exposures and favorable elimination half-lives both in rats and dogs. It demonstrated high receptor occupancy and marked wake-promoting effects with decreased rapid-eye-movement sleep in orexin-B saporin lesioned rats supporting its potential therapeutic utility in treating human sleep disorders. It had no effect on the locomotor activity at doses several fold higher than its efficacious dose. It is devoid of hERG and phospholipidosis issues. Phase-1 evaluation for safety, tolerability, and pharmacokinetics, and long-term safety studies in animals have been successfully completed without any concern for further development.