138227-63-1

Basic information

• Product Name: 1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE
• Synonyms: 4-(4-AMINO-PHENOXY)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1N-BOC 4-(4'-AMINOPHENOXY) PIPERIDINE;1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE;Boc-4-(4-amino-phenoxy)piperidine;tert-Butyl 4-(4-aminophenoxy)-1-piperidinecarboxylate;tert-Butyl 4-(4-aminophenoxy)tetrahydro-1(2H)-pyridinecarboxylate;4-{[1-(tert-Butoxycarbonyl)piperidin-4-yl]oxy}aniline;tert-Butyl 4-(4-aminophenoxy)piperidine-1-carboxylate
• CAS NO: 138227-63-1
• Molecular Formula: C₁₆H₂₄N₂O₃
• Molecular Weight: 292.37
• Product Categories: pharmacetical
• Mol File: 138227-63-1.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 430.312 °C at 760 mmHg
• Flash Point: 214.045 °C
• Appearance: /
• Density: 1.14 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE(138227-63-1)
• EPA Substance Registry System: 1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE(138227-63-1)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• Hazardous Substances Data: 138227-63-1(Hazardous Substances Data)

Usage

General Description

1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE is a chemical compound that contains a piperidine ring with a BOC (tert-butoxycarbonyl) protecting group at the nitrogen atom. Additionally, it features an amino-phenoxy group on the piperidine ring. 1-BOC-4-(4-AMINO-PHENOXY)-PIPERIDINE may be used in chemical and pharmaceutical research as a building block for the synthesis of various biologically active molecules. The BOC protecting group is commonly employed to prevent unwanted reactions at the amine group, allowing for selective functionalization elsewhere in the molecule. The presence of the amino-phenoxy group may confer specific chemical and biological properties to the compound, making it potentially useful in the development of new drugs and materials.

InChI:InChI=1/C16H24N2O3/c1-16(2,3)21-15(19)18-10-8-14(9-11-18)20-13-6-4-12(17)5-7-13/h4-7,14H,8-11,17H2,1-3H3

Upstream product

• 123-30-8 4-amino-phenol 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 141-78-6 ethyl acetate 
• 138227-62-0 tert-butyl 4-(4-nitrophenoxy)piperidine-1-carboxylate 
• 118811-07-7 tert-butyl 4-(tosyloxy)piperidin-1-carboxylate 
• 350-46-9 4-Fluoronitrobenzene 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 100-02-7 4-nitro-phenol 

Downstream Products

• 454437-33-3 N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}methanesulfonamide 
• 179756-35-5 N-{4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]phenyl}-7-cyano-2-naphthamide 
• 179755-93-2 7-({4-[(1-tert-butoxycarbonyl-4-piperidyl)oxy]-N-anilino}methyl)naphthalene-2-carbonitrile 
• 337519-64-9 N-{4-[(1-t-butoxycarbonylpiperidin)-4-yloxy]phenyl}ethanesulfonamide 
• 337519-98-9 3-((E)-3-{4-[1-(t-butoxycarbonyl)piperidin-4-yloxy]phenylamino}-1-propenyl)benzonitrile 
• 290332-75-1 ethyl (N-{4-[1-(t-butoxycarbonyl)piperidin-4-yloxy]phenyl}sulfamoyl)acetate 
• 179755-65-8 YM-60828 

Relevant articles and documents

PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CANCER

The invention provides compounds of the formula (1): or a salt or tautomer thereof wherein A, R1, R2, R3, R4, R5 and R6 are as defined herein. The compounds are inhibitors of Wee1 and/or PLK1 kinase and are envisaged to be useful in the treatment of cancers.

Catalytic Selective Oxidative Coupling of Secondary N-Alkylanilines: An Approach to Azoxyarene

Azoxyarenes are among important scaffolds in organic molecules. Direct oxidative coupling of primary anilines provides a concise fashion to construct them. However, whether these scaffolds can be prepared from secondary N-alkylanilines is not well explored. Here, we present a catalytic selective oxidative coupling of secondary N-alkylaniline to afford azoxyarene with tungsten catalyst under mild conditions. In addition, azoxy can be viewed as a bioisostere of alkene and amide. Several "azoxyarene analogues" of the corresponding bioactive alkenes and amides showed comparable promising anticancer activities.

1,3,4-OXADIAZOLE DERIVATIVE COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND THE PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to novel compounds having histone deacetylase 6 (HDAC6) in-hibitory activity, stereoisomers thereof or pharmaceutically acceptable salts thereof, the use thereof for the preparation of therapeutic medicaments, pharmaceutical compositions containing the same, a method for treating diseases using the composition, and methods for preparing the novel compounds. The novel compounds, stereoisomers thereof or pharmaceutically acceptable salts thereof according to the present invention have histone deacetylase (HDAC) inhibitory activity and are effective for the prevention or treatment of HDAC6-mediated diseases, including infectious diseases; neoplasms; endocrine, nutritional and metabolic diseases; mental and be-havioral disorders; neurological diseases; diseases of the eye and adnexa; cardiovascular diseases; respiratory diseases; digestive diseases; diseases of the skin and subcutaneous tissue; diseases of the musculoskeletal system and connective tissue; or congenital malformations, de? formations and chromosomal abnormalities.