138285-65-1 Usage
Type
Synthetic chemical compound
Potential properties
Anti-cancer properties
Studied for
Inhibiting growth of tumor cells, particularly in breast and prostate cancer
Derived from
Natural sugar inositol
Mechanism of action
Interfering with cancer cell metabolism and signaling pathways
Additional potential
Treatment for diabetes due to effects on glucose metabolism
Current status
Ongoing research to explore therapeutic applications and mechanisms of action
Check Digit Verification of cas no
The CAS Registry Mumber 138285-65-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,8,2,8 and 5 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 138285-65:
(8*1)+(7*3)+(6*8)+(5*2)+(4*8)+(3*5)+(2*6)+(1*5)=151
151 % 10 = 1
So 138285-65-1 is a valid CAS Registry Number.
InChI:InChI=1/C40H68Cl2O8/c1-22-11-12-29(45-34(22)25(4)20-41)17-30-18-31(44-10)28(7)40(47-30)27(6)19-38(9,50-40)33-13-14-37(8,48-33)36-24(3)16-32(46-36)35-23(2)15-26(5)39(43,21-42)49-35/h22-36,43H,11-21H2,1-10H3
138285-65-1Relevant articles and documents
Secondary Metabolites by Chemical Screening. 17. Nigericinol Derivatives: Synthesis, Biological Activities, and Modeling Studies
Grabley, Susanne,Hammann, Peter,Klein, Robert,Seibert, Gerhard,Winkler, Irvin,et al.
, p. 939 - 944 (1992)
The synthesis and the biological activity of C-1-reduced nigericin derivatives (nigericinols) are described and discussed.The dichloronigericinol 7 impressively demonstrated that the C-1 carboxylic acid moiety was not required for a distinct activity against bacteria and viruses.Based on the correlation between K+/H+ antiport activities and antibacterial activities it was deduced that the mode of action of the described nigericinols are related to their ionophoric properties.Molecular modeling studies showed that the efficiency of the nigericinols as ionophores correlates, qualitatively, with the probability of forming a cyclic structure, with the exception of 7.
