28380-24-7 Usage
Description
Nigericin Sodium Salt, also known as Nigericin, is a polyether antibiotic derived from Streptomyces hygroscopicus. It was first isolated in the 1950s and has a complex structure that was elucidated in 1968. Nigericin is an ionophore with a high affinity for monovalent cations such as Na+ and K+. It is known to disrupt membrane potential and the Golgi apparatus in mitochondria. Nigericin is commonly isolated as a salt and has broad biological activity against various organisms, including Gram-positive bacteria, fungi, tumor cell lines, and some viruses like HIV. It is a significant member of the polyether class and is often used as a standard for dereplication in in vitro screening bioassays.
Uses
1. Used in Pharmaceutical Industry:
Nigericin Sodium Salt is used as an ionophore for disrupting membrane potential and Golgi apparatus in mitochondria, which can have various applications in drug development and research.
2. Used in Antimicrobial Applications:
Nigericin Sodium Salt is used as an antimicrobial agent for its broad-spectrum activity against Gram-positive bacteria and fungi, making it a valuable tool in the development of new antibiotics.
3. Used in Antiviral Applications:
Nigericin Sodium Salt is used as an antiviral agent, particularly against HIV, due to its ability to disrupt the membrane potential and interfere with viral replication.
4. Used in Tumor Cell Line Research:
Nigericin Sodium Salt is used as a research tool for studying the effects of ion transport and ATPase activity in mitochondria, which can help in understanding the mechanisms of tumor cell growth and development.
5. Used in In Vitro Screening Bioassays:
Nigericin Sodium Salt is used as a standard for dereplication in in vitro screening bioassays using crude microbial extracts, helping to identify false positives and improve the accuracy of these tests.
Check Digit Verification of cas no
The CAS Registry Mumber 28380-24-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,3,8 and 0 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 28380-24:
(7*2)+(6*8)+(5*3)+(4*8)+(3*0)+(2*2)+(1*4)=117
117 % 10 = 7
So 28380-24-7 is a valid CAS Registry Number.
InChI:InChI=1/C40H68O11/c1-21-11-12-28(46-33(21)26(6)36(42)43)17-29-18-30(45-10)27(7)40(48-29)25(5)19-38(9,51-40)32-13-14-37(8,49-32)35-23(3)16-31(47-35)34-22(2)15-24(4)39(44,20-41)50-34/h21-35,41,44H,11-20H2,1-10H3,(H,42,43)/t21-,22+,23-,24-,25-,26+,27-,28?,29?,30-,31?,32?,33?,34?,35?,37+,38+,39+,40-/m1/s1
28380-24-7Relevant articles and documents
LIGAND IONOPHORE CONJUGATES
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Page/Page column 25, (2016/12/01)
The invention described herein pertains to ligand-ionophore conjugates, that may also comprise a linked therapeutic agent or imaging agent, and pharmaceutical compositions containing the conjugates. Also described are methods of using the conjugates for increasing the endosomal accumulation and escape of a therapeutic agent, or an imaging agent.
3-Imino-1,2,4-benzotriazine-1-oxides
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, (2008/06/13)
New 3-Imino-1,2,4-benzotriazine-1-oxides of formula I SPC1 wherein R represents an alkyl, alkenyl or haloalkyl radical, a phenyl or aralkyl radical optionally substituted by alkyl, alkoxy, haloalkyl, halogen or hydroxy, X and Y each independently represent hydrogen, halogen, an alkyl or alkoxy radical, or one of the two symbols represents a phenoxy or phenylsulphonyl radical optionally substituted by halogen, alkyl, haloalkyl and/or alkoxy which are active against harmful microorganisms are disclosed.
