1383612-01-8Relevant articles and documents
Asymmetric hydrogenation of ketones with H2 and ruthenium catalysts containing chiral tetradentate S2N2 ligands
Patchett, Ruth,Magpantay, Iris,Saudan, Lionel,Schotes, Christoph,Mezzetti, Antonio,Santoro, Francesco
supporting information, p. 10352 - 10355 (2013/10/21)
Getting more for less: In the presence of H2 and a base, air- and moisture-tolerant RuII complexes catalyze the hydrogenation of ketones and aldehydes with excellent activity and chemoselectivity, and with enantioselectivity of up to 95 % under mild conditions. The ratio of substrate to catalyst can be lowered to 106:1. The reactions tolerate scale-up and can be carried out with almost no solvent. A base-free method is available for base-sensitive substrates. Copyright