246139-76-4

Basic information

• Product Name: 2-BROMO-1-BROMOMETHYL-4-TERT-BUTYL-BENZENE
• Synonyms: 2-BROMO-1-BROMOMETHYL-4-TERT-BUTYL-BENZENE
• CAS NO: 246139-76-4
• Molecular Formula: C₁₁H₁₄Br₂
• Molecular Weight: 306.03686
• Product Categories: CHIRAL CHEMICALS
• Mol File: 246139-76-4.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 291.0±25.0 °C(Predicted)
• Appearance: /
• Density: 1.516±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-BROMO-1-BROMOMETHYL-4-TERT-BUTYL-BENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-1-BROMOMETHYL-4-TERT-BUTYL-BENZENE(246139-76-4)
• EPA Substance Registry System: 2-BROMO-1-BROMOMETHYL-4-TERT-BUTYL-BENZENE(246139-76-4)

Safety Data

• Hazardous Substances Data: 246139-76-4(Hazardous Substances Data)

Usage

General Description

2-Bromo-1-bromomethyl-4-tert-butyl-benzene is a chemical compound with the molecular formula C10H12Br2. It is a derivative of benzene with two bromine atoms and a tert-butyl group attached to the carbon ring. This colorless liquid is primarily used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also utilized in organic synthesis and as a chemical reagent in various reactions. The compound is considered to have low toxicity, but its handling and storage should follow proper safety measures due to its reactivity and potential health hazards.

Upstream product

• 98-51-1 4-tert-butyltoluene 
• 61024-94-0 2-bromo-4-tert-butyl-1-methylbenzene 

Downstream Products

• 349452-99-9 2-bromo-4-tert-butylmethoxymethylbenzene 
• 545395-54-8 (2E)-3-[4-(tert-butyl)-2-bromophenyl]prop-2-enoic acid 
• 545395-50-4 (2E)-N-(2H,3H-benzo[e]1,4-dioxan-6-yl)-3-[4-(tert-butyl)-2-bromophenyl]prop-2-enamide 
• 545395-56-0 ethyl 2-[(1E)-2-(N-(2H,3H-benzo[e]1,4-dioxan-6-yl)carbamoyl)vinyl]-5-(tert-butyl)benzoate 
• 351352-74-4 (E)-2-bromo-4,5'-di-tert-butyl-2'-methylstilbene 
• 351353-09-8 (E)-2,2'-dibromo-4,4'-di-tert-butylstilbene 
• 246139-77-5 2-bromo-4-(tert-butyl)benzaldehyde 
• 141-52-6 sodium ethanolate 
• 1383611-42-4 (1R,2R)-N,N-bis[4-(tert-butyl)-2-(tert-butylthio)benzylidene]-1,2-cyclohexanediamine 
• 1383612-01-8 4-(tert-butyl)-2-(tert-butylthio)benzaldehyde 
• 1332371-82-0 diethyl (2-bromo-4-tert-butylbenzyl)malonate 
• 1332371-88-6 2-(5-tert-butyl-2-ethyl-1H-inden-7-yl)-1,1,2,2-tetramethyl-N-(2-methylphenyl)disilanamine 

Relevant articles and documents

Bis-Cyclometalated Indazole Chiral-at-Rhodium Catalyst for Asymmetric Photoredox Cyanoalkylations

A new class of bis-cyclometalated rhodium(III) catalysts containing two inert cyclometalated 6-tert-butyl-2-phenyl-2H-indazole ligands and two labile acetonitriles is introduced. Single enantiomers (>99 % ee) were obtained through a chiral-auxiliary-mediated approach using a monofluorinated salicyloxazoline. The new chiral-at-metal complex is capable of catalyzing the visible-light-induced enantioselective α-cyanoalkylation of 2-acyl imidazoles in which it serves a dual function as the chiral Lewis acid catalyst for the asymmetric radical chemistry and at the same time as the photoredox catalyst for the visible-light-induced redox chemistry (up to 80 % yield, 4:1 d.r., and 95 % ee, 12 examples).

Cross-coupling strategy for the synthesis of diazocines

Ethylene bridged azobenzenes are novel, promising molecular switches that are thermodynamically more stable in the (Z) than in the (E) configuration, contrary to the linear azobenzene. However, their previous synthetic routes were often not general, and yields were poorly reproducible, and sometimes very low. Here we present a new synthetic strategy that is both versatile and reliable. Starting from widely available 2-bromobenzyl bromides, the designated molecules can be obtained in three simple steps.

Asymmetric hydrogenation of ketones with H2 and ruthenium catalysts containing chiral tetradentate S2N2 ligands

Getting more for less: In the presence of H2 and a base, air- and moisture-tolerant RuII complexes catalyze the hydrogenation of ketones and aldehydes with excellent activity and chemoselectivity, and with enantioselectivity of up to 95 % under mild conditions. The ratio of substrate to catalyst can be lowered to 106:1. The reactions tolerate scale-up and can be carried out with almost no solvent. A base-free method is available for base-sensitive substrates. Copyright