138459-91-3

Basic information

• Product Name: 3-PIVALOYLTHIAZOLIDINE-2-THION
• Synonyms: 2,2-Dimethyl-1-(2-thioxo-3-thiazolidinyl)-1-propanone;3-(2,2-Dimethyl-1-oxopropyl)-2-thiazolidinethione;3-(2,2-Dimethylpropanoyl)-1,3-thiazolidine-2-thione;3-Pivaloylthiazolidine-2-thione;2,2-diMethyl-1-(2-thioxothiazolidin-3-yl)propan-1-one
• CAS NO: 138459-91-3
• Molecular Formula: C₈H₁₃NOS₂
• Molecular Weight: 203.32492
• Product Categories: chemical additive;pharmaceutical intermediate
• Mol File: 138459-91-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 280℃
• Flash Point: 123℃
• Appearance: /
• Density: 1.22
• PKA: -1.76±0.20(Predicted)
• CAS DataBase Reference: 3-PIVALOYLTHIAZOLIDINE-2-THION(CAS DataBase Reference)
• NIST Chemistry Reference: 3-PIVALOYLTHIAZOLIDINE-2-THION(138459-91-3)
• EPA Substance Registry System: 3-PIVALOYLTHIAZOLIDINE-2-THION(138459-91-3)

Safety Data

• Hazardous Substances Data: 138459-91-3(Hazardous Substances Data)

Usage

Uses

thiazolidin e thione pharmaceutical intermediate

Upstream product

• 134469-06-0 thiazolidine-2-thione 
• 3282-30-2 pivaloyl chloride 
• 60-29-7 diethyl ether 
• 96-53-7 2-mercaptothiazoline 
• 75-98-9 Trimethylacetic acid 
• 71591-75-8 sodium 2-mercaptothiazolinate 

Downstream Products

• 929095-34-1 3-hydroxy-4-nitrobenzyl pivalate 
• 960001-08-5 1,1-dimethylethyl 4-[(3-{[(2,2-dimethyl-propanoyl)oxy]-methyl}phenyl)oxy]-piperidine-1-carboxylate 
• 426207-46-7 (E)-2-[(4'-((Trimethylacetyl)oxy)phenyl)methylidene]-10-Iododeca-3,9-diynal 
• 56619-93-3 N-(3-methoxyphenyl)pivalamide 
• 242809-41-2 Benzoic acid (R)-1-[(1R,5R,7S,8R)-7-bromomethyl-8-(2,2-dimethyl-propionyloxymethyl)-4,7-dimethyl-6-oxa-bicyclo[3.2.1]oct-3-en-5-ylmethyl]-prop-2-ynyl ester 
• 722539-68-6 2-(3-hydroxymethyl-4-hydroxyphenyl)ethylpivalate 
• 722539-66-4 2-(2-hydroxy-3-hydroxymethylphenyl)ethylpivalate 
• 960001-07-4 (3-hydroxy-phenyl)methyl 2,2-dimethyl-propanoate 
• 138488-63-8 2-(2-hydroxyphenyl)ethyl pivalate 
• 141923-60-6 2-(4-hydroxyphenyl)ethyl pivalate 
• 141923-58-2 2,2-Dimethyl-propionic acid 2-(2-hydroxy-ethyl)-cyclohexyl ester 
• 141923-57-1 2,2-Dimethyl-propionic acid 2-(2-hydroxy-cyclohexyl)-ethyl ester 

Relevant articles and documents

NOVEL VINBLASTINE DERIVATIVES, THEIR PREPARATION, USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAID DERIVATIVES

The invention provides vinblastine derivatives represented by the following formula 1 or their physiologically acceptable salts, their preparation, use and pharmaceutical compositions comprising the said derivatives. The said vinblastine derivatives show inhibiting activities against tumor cell lines and can be used as medicaments for treating malignant tumors.

2-Chloro-1,3-dimethylimidazolinium chloride. 1. A powerful dehydrating equivalent to DCC

2-Chloro-1,3-dimethylimidazolinium chloride (DMC) (3) can act as a powerful dehydrating agent, replacing DCC (1) under nearly neutral conditions. Its application to acylation and dehydration is described.

Highly chemoselective acylation of substituted aminophenols with 3-(trimethylacetyl)-1,3-thiazolidine-2-thione

A general procedure for chemoselective acylation of substituted aminophenols has been developed. The N-acetylated products 7 and 10a-h were prepared by treating the aminophenols with 3-(trimethylacetyl)-1,3-thiazolidine-2-thione (1) in refluxing THF in 70-100% yield. The esters 8 and 13d,b,j of 3- and 4-amino phenols could be obtained in 70-94% yield by treating with NaH and 1.