138499-16-8

Basic information

• Product Name: 2-(t-Butyldiphenylsilanyloxy)Ethanol
• Synonyms: 2-(t-Butyldiphenylsilanyloxy)Ethanol;2-(tert-butyldiphenylsilanyloxy)ethanol
• CAS NO: 138499-16-8
• Molecular Formula: C₁₈H₂₄O₂Si
• Molecular Weight: 300.46746
• Mol File: 138499-16-8.mol
• Article Data: 42

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(t-Butyldiphenylsilanyloxy)Ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(t-Butyldiphenylsilanyloxy)Ethanol(138499-16-8)
• EPA Substance Registry System: 2-(t-Butyldiphenylsilanyloxy)Ethanol(138499-16-8)

Safety Data

• Hazardous Substances Data: 138499-16-8(Hazardous Substances Data)

Usage

General Description

2-(t-Butyldiphenylsilanyloxy)Ethanol is a chemical compound that consists of a hydroxyl group attached to a silicon atom, with t-butyl and diphenyl groups as substituents. It is commonly used as a reagent in organic synthesis, particularly in the protection and deprotection of hydroxyl groups in organic molecules. 2-(t-Butyldiphenylsilanyloxy)Ethanol is often employed as a versatile building block in the synthesis of other organic compounds, and its unique structure and reactivity make it valuable in the production of pharmaceuticals, agrochemicals, and materials science. Additionally, it can serve as a precursor for the synthesis of various silicone-based materials due to the presence of the silicon atom in its structure.

Upstream product

• 136787-49-0 3-(tert-butyldiphenylsilyloxy)prop-1-ene 
• 107-21-1 ethylene glycol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 288-32-4 1H-imidazole 
• 130372-07-5 4-(tret-butyldiphenylsilyloxy)butan-1-ol 
• 10310-21-1 2-Amino-6-chloropurin 

Downstream Products

• 115869-43-7 (tert-butyldiphenylsilanyloxy)acetaldehyde 
• 190779-53-4 Acetic acid (2R,3R,4S,5R,6S)-3-acetoxy-2-acetoxymethyl-5-benzyloxy-6-[2-(tert-butyl-diphenyl-silanyloxy)-ethoxy]-tetrahydro-pyran-4-yl ester 
• 136022-54-3 1-(tert-butyldiphenylsiloxy)-3-methyl-2-butanone 
• 139167-05-8 1-(tert-butyldiphenylsiloxy)-3-methyl-2-butanol 
• 139167-20-7 1-(tert-butyldiphenylsiloxy)-2-cyclopropylidene-3-methylbutane 
• 139167-11-6 1-(tert-butyldiphenylsiloxy)-4-methyl-2-pentanone 
• 139167-10-5 1-(tert-butyldiphenylsiloxy)-2-hexanone 
• 139167-07-0 1-(tert-butyldiphenylsiloxy)-4-methyl-2-pentanol 
• 139167-06-9 1-(tert-butyldiphenylsiloxy)-2-hexanol 
• 139167-22-9 1-(tert-butyldiphenylsiloxy)-2-cyclopropylidene-4-methylpentane 
• 139167-21-8 1-(tert-butyldiphenylsiloxy)-2-cyclopropylidenehexane 
• 139167-12-7 (tert-butyldiphenylsiloxy)methyl p-tolyl ketone 
• 139167-13-8 (tert-butyldiphenylsiloxy)methyl p-methoxyphenyl ketone 
• 139167-08-1 2-(tert-butyldiphenylsiloxy)-1-(p-tolyl)-1-ethanol 

Relevant articles and documents

NOVEL CARBONATE ANALOGUES BEARING PTEROSTILBENE AMINO ACIDS FOR THE TREATMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE AND NON-ALCOHOLIC STEATOHEPATITIS

A series of novel analogs of water soluble pterostilbene amino acid bearing carbonates were synthesized, which show activities in treating a non-alcoholic fatty liver disease and a nonalcoholic steatohepatitis (NASH).

Ambruticins: tetrahydropyran ring formation and total synthesis

The ambruticins are a family of polyketide natural products which exhibit potent antifungal activity. Gene knockout experiments are in accord with the proposal that the tetrahydropyran ring of the ambruticins is formedviathe AmbJ catalysed epoxidation of the unsaturated 3,5-dihydroxy acid, ambruticin J, followed by regioselective cyclisation to ambruticin F. Herein, a convergent approach to the total synthesis of ambruticin J is described as well as model studies involving epoxidation and cyclisations of unsaturated hydroxy esters to give tetrahydropyrans and tetrahydrofurans. The total synthesis involves preparation of three key fragments which were unitedviaa Suzuki-Miyaura cross-coupling and Julia-Kocienski olefination to generate the required carbon framework. Global deprotection to a triol and selective oxidation of the primary alcohol gave, after hydrolysis of the lactone, ambruticin J.

Total Synthesis of Citreochlorol Monochloro Analogues via a Catalytically Enantioselective Carbonyl Allylation

An efficient synthetic route to citreochlorol analogues, halogenated polyketide secondary metabolites, is described. The key features are Krische s enantioselective carbonyl allylation, IBr-promoted cyclization, and regioselective epoxide opening. The importance of the route lies in accessing a versatile epoxy ether that enables the formation of citreochlorol monochloro derivatives.