1385026-24-3Relevant articles and documents
Regioselective synthesis of the 1-bromo-4-phenyl-tetrahydro-7-amino- benzocyclohepten-6-one, a subnanomolar aminopeptidase-N/CD13 inhibitor
Al-Lakkis-Wehbe, Mira,Roux, Lionel,Charrier, Cédric,Alavi, Sarah,Le Nou?n, Didier,Defoin, Albert,Tarnus, Céline,Albrecht, Sébastien
experimental part, p. 6447 - 6455 (2012/08/28)
A regioselective synthesis of the title 1-bromo-4-phenyl-tetrahydro-7- amino-benzocyclohepten-6-one 2 has been pursued and develop in order to allow a large scale synthesis of this highly potent and selective APN inhibitor (K i 60 pM). The pivo
