1392843-27-4Relevant articles and documents
Biosynthetically intriguing chlorinated lipophilic metabolites from geographically distant tropical marine cyanobacteria
Nunnery, Joshawna K.,Engene, Niclas,Byrum, Tara,Cao, Zhengyu,Jabba, Sairam V.,Pereira, Alban R.,Matainaho, Teatulohi,Murray, Thomas F.,Gerwick, William H.
, p. 4198 - 4208 (2012/06/18)
Five new vinylchlorine-containing metabolites, the lipoamides janthielamide A and kimbeamides A-C and the ketide-extended pyranone kimbelactone A, have been isolated from collections of marine cyanobacteria made in Curacao and Papua New Guinea. Both janthielamide A and kimbeamide A exhibited moderate sodium channel blocking activity in murine Neuro-2a cells. Consistent with this activity, janthielamide A was also found to antagonize veratridine-induced sodium influx in murine cerebrocortical neurons. These lipoamides represent the newest additions to a relatively rare family of marine cyanobacterial-derived lipoamides and a new structural class of compounds exhibiting neuromodulatory activities from marine cyanobacteria.