44565-27-7

Basic information

• Product Name: 4-AMINO-2-METHYL-1-BUTANOL
• Synonyms: 4-AMINO-2-METHYLBUTANOL;4-AMINO-2-METHYL-1-BUTANOL;4-AMINO-2-METHYLBUTANOL 98+% GC;4-Amino-2-methylbutan-1-ol
• CAS NO: 44565-27-7
• Molecular Formula: C₅H₁₃NO
• Molecular Weight: 103.16
• Mol File: 44565-27-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 106.3-108.5 °C
• Boiling Point: 174.682°C at 760 mmHg
• Flash Point: 59.446°C
• Appearance: /
• Density: 0,94 g/cm3
• Vapor Pressure: 0.369mmHg at 25°C
• Refractive Index: 1.4600-1.4630
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 14.96±0.10(Predicted)
• CAS DataBase Reference: 4-AMINO-2-METHYL-1-BUTANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-2-METHYL-1-BUTANOL(44565-27-7)
• EPA Substance Registry System: 4-AMINO-2-METHYL-1-BUTANOL(44565-27-7)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-41-37/38-22
• Safety Statements: 26-36/37/39-39
• Hazardous Substances Data: 44565-27-7(Hazardous Substances Data)

Usage

General Description

4-Amino-2-methyl-1-butanol is a chemical compound with the molecular formula C5H13NO. It is a primary aliphatic amine that has a butanol structure with a methyl and amino group attached to the second carbon. 4-AMINO-2-METHYL-1-BUTANOL has a variety of industrial and laboratory applications, including use as a chemical intermediate in the production of pharmaceuticals, dyes, and agricultural chemicals. It is also used as a building block in the synthesis of surfactants and other organic compounds. Additionally, 4-amino-2-methyl-1-butanol has been studied for its potential use in organic synthesis and medicinal chemistry.

InChI:InChI=1/C5H13NO/c1-5(4-7)2-3-6/h5,7H,2-4,6H2,1H3

Upstream product

• 42453-21-4 4-Amino-2-methylbutyric acid 
• 13931-35-6 4-(Tetrahydro[2H]pyran-2-yloxy)-3-methyl-2-butenenitrile 
• 78-92-2 iso-butanol 
• 63987-58-6 rac-2-methyl-4-phthalimidobutanoic acid 
• 63987-58-6 (R)-2-methyl-4-phthalimido-butyric acid 
• 201230-82-2 carbon monoxide 
• 109-75-1 but-3-enenitrile 
• 96192-37-9 (R)-2MeGABA 
• 73616-96-3 (S)-4-hydroxy-3-methyl-butyronitrile 

Downstream Products

• 1028119-65-4 2-methyl-4-(2-nitrobenzylamino)butanol 
• 1265404-86-1 3-[1-(4-hydroxy-3-methylbutylcarbamoyl)-3-methylbutylcarbamoyl]-oxirane-2-carboxylic acid ethyl ester 
• 131176-14-2 3-[1-(4-hydroxy-3-methylbutylcarbamoyl)-3-methylbutylcarbamoyl]-oxirane-2-carboxylic acid 
• 1265404-73-6 [1-(4-hydroxy-3-methylbutylcarbamoyl)-3-methylbutyl]-carbamic acid tert-butyl ester 
• 1392843-27-4 C₇H₁₃NO₃ 
• 1392843-04-7 C₁₅H₂₉NO₃ 
• 404849-99-6 C₉H₁₇NO₃ 
• 1392843-19-4 C₇H₁₃NO₃ 
• 1392842-92-0 C₁₅H₂₉NO₃ 
• 404849-98-5 C₉H₁₇NO₃ 
• 1437-87-2 4-Amino-2-methyl-butylhydrogensulfat 

Relevant articles and documents

Synthesis and application of a new bisphosphite ligand collection for asymmetric hydroformylation of allyl cyanide

A series of mono- and bidentate phosphites was prepared with (S)-5,5',6,6'-tetramethyl-3,3'-di-tertbutyl-1,1'-biphenyl-2,2'-dioxy [(S)-BIPHEN] as a chiral auxiliary and screened in the asymmetric hydroformylation of allyl cyanide. These hydroformylation results were compared with those of two existing chiral ligands, Chiraphite and BINAPHOS, whose utility in asymmetric hydroformylation has been previously demonstrated. Bisphosphite 11 with a 2,2'-biphenol bridge was found to be the best overall ligand for asymmetric hydroformylation of allyl cyanide with up to 80% ee and regioselectivities (branch-to-linear ratio, b/l) of 20 with turnover frequency of 625 [h-1] at 35 °C. BINAPHOS gave enantioselectivities up to 77% ee when the reaction was conducted in either acetone or neat but with poor regioselectivity (b/l 2.8) and activities 7 times lower than that of 11. The product of allyl cyanide hydroformylation using (R,R)-11 was subsequently transformed into (R)-2-methyl-4-aminobutanol, a useful chiral building block. Single-crystal X-ray structures of (S,S)-11 and its rhodium complex 19 were determined.

APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS AND USES THEREOF

Described herein are ASK1 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of blood disease, autoimmune disorders, pulmonary disorders, hypertension, inflammatory diseases, fibrotic diseases, diabetes, diabetic nephropathy, renal diseases, respiratory diseases, cardiovascular diseases, acute lung injuries, acute or chronic liver diseases, and neurodegenerative diseases.

PROCESS FOR PRODUCING OPTICALLY ACTIVE AMINOALCOHOL

An industrially advantageous process for producing optically active 4-amino-2-methylbutane-1-ol which is useful as an intermediate in synthesizing optically active medicines and pesticides. Racemic 4-amino-2-methylbutane-1-ol is treated with an optically active organic acid. The diastereomeric salt thus obtained is crystallized out and subjected to solid-liquid separation to give optically active 4-amino-2-methylbutane-1-ol. The diastereomeric salt of optically active 4-amino-2-methylbutane-1-ol with an optically active reagent for optical resolution is decomposed by bringing into contact with a solvent and an alkali and subjected to solid-liquid separation, thereby recovering the optically active 4-amino-2-methylbutane-1-ol from the filtrate. Further, the filtration residue containing the alkali salt of the reagent for optical resolution obtained by the solid-liquid separation is brought into contact with a solvent and an acid. Then the reagent for optical resolution thus crystallized out is subjected to solid-liquid separation and recovered.