1393603-63-8

Basic information

• Product Name: C₃₃H₄₅NO₇Si
• Synonyms: C₃₃H₄₅NO₇Si
• CAS NO: 1393603-63-8
• Molecular Weight: 595.808
• Mol File: 1393603-63-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₃H₄₅NO₇Si(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₃H₄₅NO₇Si(1393603-63-8)
• EPA Substance Registry System: C₃₃H₄₅NO₇Si(1393603-63-8)

Safety Data

• Hazardous Substances Data: 1393603-63-8(Hazardous Substances Data)

Upstream product

• 1484-84-0 2(RS)-(2-hydroxyethyl)piperidine 
• 1202039-12-0 (+)-(2R)-(2-oxopropyl)piperidine-1-carbamic acid tert-butylester 
• 1248344-23-1 4-(methoxymethoxy)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde 
• 1393603-29-6 C₁₃H₂₅NO₃ 
• 1393603-30-9 (R,E)-tert-butyl-2-(4-(2-iodo-4,5-dimethoxyphenyl)-2-oxobut-3-enyl)piperidine-1-carboxylate 
• 1393603-26-3 C₁₇H₂₂INO₃ 
• 1393603-37-6 (4S,9aR)-hexahydro-4-(2-(2'-methoxymethoxy-5'-carboxaldehyphenyl)-4,5-dimethoxyphenyl)-1H-quinolizin-2(6H)-one 
• 394657-61-5 (diphenoxy-phosphoryl)acetic acid 2-trimethylsilanyl-ethyl ester 
• 1393603-28-5 C₇H₁₅NO*C₁₀H₁₆O₄S 
• 639458-46-1 (R)-2-(2-oxo-ethyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 250249-85-5 (R)-2-(2-hydroxy-ethyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 121169-17-3 3-iodo-4-(methoxymethoxy)benzaldehyde 
• 79414-13-4 trimethylsilylethyl bromoacetate 
• 60032-63-5 4-hydroxy-3-iodo-benzaldehyde 

Relevant articles and documents

Asymmetric synthesis of (+)-vertine and (+)-lythrine

The total syntheses of the Lythracea alkaloids (+)-vertine and (+)-lythrine are described. Enantioenriched pelletierine is used as a chiral building block and engaged into a two step pelletierine condensation leading to two quinolizidin-2-one diastereomers in a 8:1 ratio. The major product is used in the synthesis of (+)-vertine via aryl-aryl coupling and ring closing metathesis to provide a Z-alkene α to the lactone carbonyl function. The same procedure was used for (+)-lythrine after base induced epimerization of the main quinolizidin-2-one diastereomer. Alternative classical ring closure strategies like macrolactonisation or aryl-aryl coupling failed.