1394120-92-3Relevant articles and documents
Back pocket flexibility provides group II p21-activated kinase (PAK) selectivity for type i 1/2 kinase inhibitors
Staben, Steven T.,Feng, Jianwen A.,Lyle, Karen,Belvin, Marcia,Boggs, Jason,Burch, Jason D.,Chua, Ching-Ching,Cui, Haifeng,Dipasquale, Antonio G.,Friedman, Lori S.,Heise, Christopher,Koeppen, Hartmut,Kotey, Adrian,Mintzer, Robert,Oh, Angela,Roberts, David Allen,Rouge, Lionel,Rudolph, Joachim,Tam, Christine,Wang, Weiru,Xiao, Yisong,Young, Amy,Zhang, Yamin,Hoeflich, Klaus P.
, p. 1033 - 1045 (2014/03/21)
Structure-based methods were used to design a potent and highly selective group II p21-activated kinase (PAK) inhibitor with a novel binding mode, compound 17. Hydrophobic interactions within a lipophilic pocket past the methionine gatekeeper of group II
