1394346-24-7

Basic information

• Product Name: (R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine
• Synonyms: (R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine
• CAS NO: 1394346-24-7
• Molecular Weight: 410.027
• Mol File: 1394346-24-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine(1394346-24-7)
• EPA Substance Registry System: (R)-5-bromo-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine(1394346-24-7)

Safety Data

• Hazardous Substances Data: 1394346-24-7(Hazardous Substances Data)

Upstream product

• 877397-65-4 (S)‐1‐(2,6-dichloro-3-fluorophenyl)ethanol 
• 691872-15-8 5-bromo-3-hydroxy-2-nitropyridine 
• 74115-13-2 5-bromopyridine-3-ol 

Downstream Products

• 1448326-33-7 5-bromo-3-[1 (R)-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-2-ylamine 
• 1394346-15-6 (R)-(4-(6-amino-5-(1-(2,6-dichloro-3-fluorophenyl)-ethoxy)pyridin-3-yl)-3-fluorophenyl)dimethylphosphine oxide 
• 1428476-86-1 4-(4-{6-amino-5-[(R)-1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-pyridin-3-yl}-pyrazol-1-yl)-piperidine-1-carboxylic acid tert-butyl ester 
• 877399-52-5 crizotinib 

Relevant articles and documents

Development of a modified process for the kilogram-scale synthesis of c-Met/ALK inhibitor HS-10168

A modified synthetic route to c-Met/ALK inhibitor HS-10168 has been developed on a kilogram scale. The key steps of the new process include a Suzuki coupling reaction of nitro-containing bromopyridine 6 and para-phenol boronate 9 to give intermediate 10, which was then converted to its triflate 11. The phosphorus group was introduced by coupling of 11 and dimethylphoshine oxide 8 to give compound 12, which was reduced to produce HS-10168.

PHOSPHORUS CONTAINING COMPOUNDS AS PROTEIN KINASE INHIBITORS

The present invention relates to compounds represented by formula (I), which can modulate the activity of protein kinases. The invention also relates to a composition containing a compound of formula (I), and a method for synthesizing and using such compound for preventing or treating ALK or cMet mediated disorders or conditions.