1395418-46-8

Basic information

• Product Name: 1-butyl-2-(4-fluorophenyl)-1H-quinolin-4-one
• Synonyms: 1-butyl-2-(4-fluorophenyl)-1H-quinolin-4-one
• CAS NO: 1395418-46-8
• Molecular Weight: 295.356
• Mol File: 1395418-46-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-butyl-2-(4-fluorophenyl)-1H-quinolin-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-butyl-2-(4-fluorophenyl)-1H-quinolin-4-one(1395418-46-8)
• EPA Substance Registry System: 1-butyl-2-(4-fluorophenyl)-1H-quinolin-4-one(1395418-46-8)

Safety Data

• Hazardous Substances Data: 1395418-46-8(Hazardous Substances Data)

Upstream product

• 109-73-9 N-butylamine 
• 95895-33-3 1-(bromoethynyl)-4-fluorobenzene 
• 159957-00-3 1-(2,2-dibromovinyl)-4-fluorobenzene 
• 1395418-36-6 1-(2-chlorophenyl)-3-(4-fluorophenyl)propyn-1-one 

Relevant articles and documents

Transition-Metal-Free One-Pot Tandem Synthesis of 4-Quinolone and 4 H -Thiochromen-4-one Derivatives Through Sequential Nucleophilic Addition-Elimination-S N Ar Reaction

4-Quinolone and 4 H -thiochromen-4-one derivatives are readily synthesized in a tandem one-pot manner in good to excellent yields. Starting from (Z)-β-chlorovinyl ketones, an intermolecular nucleo-philic addition of amines or sodium hydrogen sulfide to (Z

Synthesis of N-alkyl-substituted 4-quinolones via tandem alkenyl and aryl C-N bond formation

N-Alkyl-substituted 4-quinolones are present as the key structural motif in many marketed drugs. An efficient one-step tandem amination approach was developed to afford N-alkyl-substituted 4-quinolones in high yields from easily accessible o-chloroaryl acetylenic ketones and functionalized alkyl amines. The approach complements and extends our previous work. Compared with other reported methods, the current method provides a very simple and convenient route. Georg Thieme Verlag Stuttgart · New York.