139893-81-5 Usage
Description
(1S,4S,5S)-4-bromo-6-oxabicyclo<3.2.1>octan-7-one is a chiral cycloalkanone derivative with the molecular formula C8H11BrO2. It features a bromine atom and a heterocyclic oxygen ring, and is classified as a bicyclic compound due to its two interconnected ring structures. This unique structural feature and potential reactivity may make it a valuable compound in various fields.
Uses
Used in Organic Synthesis:
(1S,4S,5S)-4-bromo-6-oxabicyclo<3.2.1>octan-7-one is used as a key intermediate in organic synthesis for the preparation of various complex organic molecules. Its unique structure and reactivity make it a promising candidate for the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Medicinal Chemistry:
(1S,4S,5S)-4-bromo-6-oxabicyclo<3.2.1>octan-7-one is used as a building block in medicinal chemistry for the development of new drugs and drug candidates. Its chiral centers and heterocyclic ring system can be exploited to create novel bioactive compounds with potential therapeutic applications.
Used in Material Science:
(1S,4S,5S)-4-bromo-6-oxabicyclo<3.2.1>octan-7-one is used as a component in the development of new materials with unique properties. Its structural features may contribute to the creation of advanced materials for applications in various industries, such as electronics, coatings, and adhesives.
Check Digit Verification of cas no
The CAS Registry Mumber 139893-81-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,9,8,9 and 3 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 139893-81:
(8*1)+(7*3)+(6*9)+(5*8)+(4*9)+(3*3)+(2*8)+(1*1)=185
185 % 10 = 5
So 139893-81-5 is a valid CAS Registry Number.
139893-81-5Relevant articles and documents
Development of an Efficient Manufacturing Process for a Key Intermediate in the Synthesis of Edoxaban
Michida, Makoto,Ishikawa, Hideaki,Kaneda, Takeshi,Tatekabe, Shinya,Nakamura, Yoshitaka
, p. 524 - 534 (2019)
We report the development of a novel synthetic method to access a key intermediate in the synthesis of edoxaban. The main features of the new synthetic method are an improvement in the approach for the synthesis of a key chiral bromolactone, application of an interesting cyclization reaction utilizing neighboring group participation to construct a differentially protected 1,2-cis-diamine, and implementation of plug-flow reactor technology to enable the reaction of an unstable intermediate on multihundred kilogram scale. The overall yield for the preparation of edoxaban was significantly increased by implementing these changes and led to a more efficient and environmentally friendly manufacturing process.
