14017-81-3

Basic information

• Product Name: 4-Hexenoic acid, methyl ester, (4E)-
• Synonyms: Methyl (4E)-hex-4-enoate;4-Hexenoic acid, methyl ester, (E)- (8CI);Methyl trans-4-hexenoate
• CAS NO: 14017-81-3
• Molecular Formula: C₇H₁₂O₂
• Molecular Weight: 128.171
• Mol File: 14017-81-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 126 °C at 760 mmHg
• Flash Point: 40.1 °C
• Density: 0.907 g/cm³
• CAS DataBase Reference: 4-Hexenoic acid, methyl ester, (4E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hexenoic acid, methyl ester, (4E)-(14017-81-3)
• EPA Substance Registry System: 4-Hexenoic acid, methyl ester, (4E)-(14017-81-3)

Safety Data

• Hazardous Substances Data: 14017-81-3(Hazardous Substances Data)

Usage

General Description

4-Hexenoic acid, methyl ester, (4E)- is a chemical compound with the molecular formula C8H14O2. It is also known as hex-4-enoic acid methyl ester and has a slightly fruity, floral odor. 4-Hexenoic acid, methyl ester, (4E)- is used as a flavoring agent in the food industry, particularly in the production of fruit and berry flavors. It is also used in the fragrance industry for its sweet and fruity aroma, often being used in perfumes, colognes, and other scented products. Additionally, 4-Hexenoic acid, methyl ester, (4E)- has potential applications in the pharmaceutical industry as a building block for the synthesis of various drugs and pharmaceutical compounds.

Upstream product

• 1918-79-2 2-methylthiophene-5-carboxylic acid 
• 67-56-1 methanol 
• 124-38-9 carbon dioxide 
• 35194-36-6 hex-4-enoic acid 
• 74-88-4 methyl iodide 

Relevant articles and documents

Tandem RCM of Dienynes for the Construction of Taxol-Type Carbocyclic Systems

(Matrix presented) Tandem ring-closing metathesis of hydrindanone dienynes allows access to taxosteroids, a new class of compounds that combine the [5.3.1] carbocyclic system of taxanes with rings C and D of the steroid skeleton.

Lithium/Ammonia Reductions of 2-Thiophenecarboxylic Acids

Lithium/ammonia reductions of 2-thiophenecarboxylic acids (1) in the absence of a proton source afforded mixtures of products.In the presence of methanol acyclic mercapto carboxylic acids (4) were the major products.Ring closure of 4 to the corresponding thiolactones (12) showed the double bonds in 4 to be of cis geometry.Attempts were made to prepare Z olefinic compounds derived from these mercapto carboxylic acids.Lithium 2-thiophenecarboxylate salts (2) afforded good yields of the corresponding 2,5-dihydro-2-thiophenecarboxylic acids (3).The presence of substituents on the ring and the ratio of metal to acid were significant factors in determining the nature of this products.A mechanism is proposed to explain the products observed.