1401856-10-7Relevant articles and documents
Enantioselective organocatalytic domino synthesis of tetrahydropyridin-2- ols
Wan, Jie-Ping,Loh, Charles C. J.,Pan, Fangfang,Enders, Dieter
, p. 10049 - 10051 (2012/11/07)
The asymmetric synthesis of tetrahydropyridin-2-ols from enals and enaminones is described. The organocatalytic domino reaction involves a Michael addition-hemiaminalization sequence using the Jorgensen-Hayashi catalyst. Dehydration or oxidation leads to the corresponding 1,4-dihydro-pyridines or 3,4-dihydropyridin-2-ones in a one-pot fashion. The Royal Society of Chemistry 2012.