1404231-92-0Relevant articles and documents
Rh-catalyzed addition of arylboroxines to cyclic N -(Isopropanesulfinyl) ketimines
Jung, Hyung Hoon,Buesking, Andrew W.,Ellman, Jonathan A.
, p. 9593 - 9600,8 (2012/12/12)
Arylboroxines, which are easily accessed by drying commercially available arylboronic acids, are added to N-(isopropanesulfinyl)ketimines derived from cyclohexanone, N-Boc-piperidin-4-one, and tetrahydropyran-4-one in high yields and with excellent functional group compatibility via rhodium catalysis. These results contrast with additions to the corresponding ketimines incorporating the larger N-tert-butanesulfinyl group, which give considerably lower yields. Efficient two-step preparation of racemic isopropanesulfinamide from inexpensive isopropyl disulfide and recycling of the isopropanesulfinyl group from the addition products are also described.
