98527-70-9

Basic information

• Product Name: tris(3-bromo phenyl)boroxine
• Synonyms: tris(3-bromo phenyl)boroxine
• CAS NO: 98527-70-9
• Molecular Weight: 548.436
• Mol File: 98527-70-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: tris(3-bromo phenyl)boroxine(CAS DataBase Reference)
• NIST Chemistry Reference: tris(3-bromo phenyl)boroxine(98527-70-9)
• EPA Substance Registry System: tris(3-bromo phenyl)boroxine(98527-70-9)

Safety Data

• Hazardous Substances Data: 98527-70-9(Hazardous Substances Data)

Upstream product

• 873-51-8 phenylborondichloride 
• 7726-95-6 bromine 
• 688-74-4 boric acid tributyl ester 
• 18620-02-5 (4-bromophenyl)magnesium bromide 
• 89598-96-9 (3-bromophenyl)boronic acid 

Downstream Products

• 25487-66-5 3-Carboxyphenylboronic acid 
• 87199-16-4 3-Formylphenylboronic acid 
• 108-86-1 bromobenzene 
• 56911-48-9 diethyl (3-bromophenyl)malonate 
• 1404231-92-0 N-4-(4-(3-bromophenyl)tetrahydropyranyl)isopropanesulfinylamine 

Relevant articles and documents

A process for preparing aldehyde group benzene boric acid

The invention discloses a method for preparing formyl phenylboronic acid, which comprises the following steps: heating halogenated phenylboronic acid in toluene or heptane under reflux for dewatering to form a tripolymer, mixing the tripolymer with dimethylformamide, dropwisely adding n-butyllithium at low temperature to react by a one-pot process, hydrolyzing with hydrochloric acid, and recrystallizing to obtain the formyl phenylboronic acid. The method is simple to operate, avoids the process of separating the intermediate after formyl protection in the conventional technique, has high universality, can obtain favorable yield for ortho-, meta- and para- formyl phenylboronic acids, and is beneficial to scale-up production.

Palladium(II)-Catalyzed Enantioselective Synthesis of α-(Trifluoromethyl)arylmethylamines

We describe a method for the synthesis of α-(trifluoromethyl)arylmethylamines that consists of the palladium(II)-catalyzed addition of arylboroxines to imines derived from trifluoroacetaldehyde. Palladium acetate is used as a catalyst with electron-neutral or electron-rich arylboroxines, and it was found that addition of an ammonium or silver salt was crucial to promote the reaction of electron-poor boroxines. With (S)-t-Bu-PyOX as the chiral ligand, this method delivers a variety of α-trifluoromethylated amines in 57-91% yield and with greater than 92% ee in most cases.

Rh-catalyzed addition of arylboroxines to cyclic N -(Isopropanesulfinyl) ketimines

Arylboroxines, which are easily accessed by drying commercially available arylboronic acids, are added to N-(isopropanesulfinyl)ketimines derived from cyclohexanone, N-Boc-piperidin-4-one, and tetrahydropyran-4-one in high yields and with excellent functional group compatibility via rhodium catalysis. These results contrast with additions to the corresponding ketimines incorporating the larger N-tert-butanesulfinyl group, which give considerably lower yields. Efficient two-step preparation of racemic isopropanesulfinamide from inexpensive isopropyl disulfide and recycling of the isopropanesulfinyl group from the addition products are also described.