140428-44-0

Basic information

• Product Name: 1-bromo-3-phenoxy-propan-2-ol
• CAS NO: 140428-44-0
• Molecular Weight: 231.089
• Mol File: 140428-44-0.mol
• Article Data: 45

Chemical Properties

• CAS DataBase Reference: 1-bromo-3-phenoxy-propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-bromo-3-phenoxy-propan-2-ol(140428-44-0)
• EPA Substance Registry System: 1-bromo-3-phenoxy-propan-2-ol(140428-44-0)

Safety Data

• Hazardous Substances Data: 140428-44-0(Hazardous Substances Data)

Upstream product

• 3132-64-7 1,2-Epoxy-3-bromopropane 
• 108-95-2 phenol 
• 2930-05-4 Benzyloxymethyl-oxiran 
• 122-60-1 Phenyl glycidyl ether 
• 868-26-8 dimethyl 2-bromomalonate 
• 1746-13-0 allyl phenyl ether 
• 95-56-7 2-hydroxybromobenzene 
• 538-43-2 3-phenoxy-1,2-propanediol 
• 925-90-6 ethylmagnesium bromide 
• 142072-04-6 Benzoic acid 1-bromomethyl-2-phenoxy-ethyl ester 
• 22421-56-3 2-(2,3-epoxypropoxy)phenyl bromide 

Downstream Products

• 4437-83-6 4-(phenoxy)methyl-1,3-dioxolane-2-one 
• 96-21-9 1,3-dibromo-2-hydroxypropane 
• 635320-91-1 1-benzyl-2-imino-3-(2-hydroxy-3-phenoxypropyl)benzimidazole hydrobromide 
• 84137-77-9 1-phenoxy-3-(phenylthio)propan-2-ol 
• 140630-39-3 (S)-3-bromo-1-phenoxy-2-propanol 
• 140630-35-9 (R)-3-bromo-1-phenoxy-2-propanol 
• 140630-40-6 Acetic acid (R)-1-bromomethyl-2-phenoxy-ethyl ester 
• 140630-36-0 Acetic acid (S)-1-bromomethyl-2-phenoxy-ethyl ester 

Relevant articles and documents

A mild and efficient procedure for the oxidation of epoxides and aziridines using cerium(IV) ammonium nitrate and NBS

The CAN and NBS combination has been used for the first time for the synthesis of versatile α-hydroxy ketones and α-amino ketones from oxiranes/aziridines, respectively, in excellent yields. This method is a direct, one-pot, synthesis under mild conditions using acetonitrile-water (9:1) as solvent.

A Facile and Highly Regioselective Conversion of Epoxides to Bromohydrins Using Tetrabutylammonium Bromide and Magnesium Nitrate

Reaction of epoxides with nBu4NBr in the presence of Mg(NO3)2 as a catalyst affords vicinal bromohydrins in excellent yields via regioselective ring opening of the unsymmetrical epoxides.

Visible-light-triggered Catalytic Halohydrin Synthesis from Epoxides and Trichloroacetonitrile by Copper and Iron Salts

Preparation of vicinal halohydrins, in which copper or iron chlorides catalyze the ring-opening reaction of epoxides with visible light effectively, is described. The use of trichloroacetonitrile as a halogen source enables catalytic HCl generation under the mild conditions. This method can also be applied to the aziridine ring-opening reaction.

Highly enantioselective CALB-catalyzed kinetic resolution of building blocks for β-blocker atenolol

Both enantiomers of 4-(3-chloro-2-hydroxypropoxy)phenyl)acetamide has been synthesized in 98.5–99% enantiomeric excess by use of lipase B from Candida antarctica as catalyst. The R-alcohol is a building block for the cardioselective β-blocker (S)-atenolol ((S)-2-(4-(2-hydroxy-3-(isopropylamino)propoxy)phenyl)acetamide. Performing kinetic resolutions of 3-chloro-1-phenoxy-2-propanol and 3-bromo-1-phenoxy-2-propanol with vinyl butanoate as acyl donor and the same CALB enzyme, but a different preparation, showed higher E-values than previously reported.