1407513-29-4

Basic information

• Product Name: 2-chloro-6-methyl-3-(phenylethynyl)quinoxaline
• Synonyms: 2-chloro-6-methyl-3-(phenylethynyl)quinoxaline
• CAS NO: 1407513-29-4
• Molecular Weight: 278.741
• Mol File: 1407513-29-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-chloro-6-methyl-3-(phenylethynyl)quinoxaline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-6-methyl-3-(phenylethynyl)quinoxaline(1407513-29-4)
• EPA Substance Registry System: 2-chloro-6-methyl-3-(phenylethynyl)quinoxaline(1407513-29-4)

Safety Data

• Hazardous Substances Data: 1407513-29-4(Hazardous Substances Data)

Upstream product

• 6309-61-1 6-methylquinoxaline-2,3-dione 
• 496-72-0 4-methyl-1,2-diaminobenzene 
• 39267-05-5 2,3-dichloro-6-methylquinoxaline 
• 536-74-3 phenylacetylene 

Downstream Products

• 1407513-34-1 6-methyl-2-phenyl-1H-pyrrolo[2,3-b]quinoxaline 
• 1446432-83-2 (Z)-2-(2,4-diethoxyphenyl)-3-(2-(2,4-diethoxyphenyl)-2-phenylvinyl)-6-methylquinoxaline 
• 1446432-82-1 (Z)-2-(2,4-dimethoxy-3-methylphenyl)-3-(2-(2,4-dimethoxy-3-methylphenyl)-2-phenylvinyl)-6-methylquinoxaline 
• 1446432-80-9 (Z)-4-(3-(2-(2,4-dihydroxy-3-methylphenyl)-2-phenylvinyl)-6-methylquinoxalin-2-yl)-2-methylbenzene-1,3-diol 
• 1446432-79-6 (Z)-4-(3-(2-(2,4-dihydroxyphenyl)-2-phenylvinyl)-6-methylquinoxalin-2-yl)benzene-1,3-diol 
• 1448176-16-6 6-methyl-2-phenylfuro[2,3-b]quinoxaline 

Relevant articles and documents

Regioselective 6-endo-dig iodocyclization: An accessible approach for iodo-benzo [a] phenazines

A facile approach for the synthesis of substituted iodo-benzo[a]phenazines from 2-aryl-3-(aryl/alkylethynyl)quinoxalines via 6-endo-dig ring closure has been described under mild reaction conditions. Iodocyclization proceeds through the iodonium ion intermediate followed by nucleophilic cyclization with the C-H bond of the arene. Furthermore, the resulting 6-iodo-5-aryl/alkyl benzo[a]phenazine derivatives allowed for structural diversification by employing various coupling reactions. The structure of iodo-benzo[a]phenazine was confirmed by X-ray crystallographic studies of the compound.

Transition metal free hydrolysis/cyclization strategy in a single pot: Synthesis of fused furo N-heterocycles of pharmacological interest

A transition metal free tandem two-step strategy has been developed involving hydrolysis of 2-chloro-3-alkynyl quinoxalines/pyrazines followed by in situ cyclization of the corresponding 2-hydroxy-3-alkynyl intermediates in a single pot leading to fused furo N-heterocycles as potential inhibitors of sirtuins. A representative compound showed promising pharmacological properties in vitro and in vivo.

AlCl3-mediated hydroarylation-heteroarylation in a single pot: A direct access to densely functionalized olefins of pharmacological interest

An unprecedented AlCl3-mediated method has been developed involving aromatic C-H bond addition to an alkyne and heteroarylation of an arene in a single pot leading to densely functionalized novel olefins, e.g. 2-(2,2-diarylvinyl)-3-arylquinoxalines, as potential inhibitors of sirtuins.