6309-61-1

Basic information

• Product Name: 1,4-DIHYDRO-6-METHYLQUINOXALINE-2,3-DIONE
• Synonyms: 1,4-DIHYDRO-6-METHYLQUINOXALINE-2,3-DIONE;2,3-DIHYDROXY-6-METHYLQUINOXALINE;6-METHYLQUINOXALINE-2,3-DIOL;6-METHYL-1,4-DIHYDROQUINOXALINE-2,3-DIONE;2,3-Dihydoxy-6-methylquinoxaline;1,4-DIHYDRO-6-METHYLQUINOLAXINE-2,3-DIONE;1,4-Dihydro-6-Methyl-2,3-quinoxalinedione;6-Methylquinoxaline-2,3-diol C9H8N2O2 [6309-61-1]
• CAS NO: 6309-61-1
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176.17
• EINECS: 228-628-2
• Mol File: 6309-61-1.mol
• Article Data: 20

Chemical Properties

• Melting Point: 112 °C
• Boiling Point: 467 °C at 760 mmHg
• Flash Point: 236.2 °C
• Appearance: /
• Density: 1.28 g/cm³
• Vapor Pressure: 2.42E-09mmHg at 25°C
• Refractive Index: 1.576
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: slightly sol. in Dimethylformamide
• PKA: 10.61±0.20(Predicted)
• CAS DataBase Reference: 1,4-DIHYDRO-6-METHYLQUINOXALINE-2,3-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-DIHYDRO-6-METHYLQUINOXALINE-2,3-DIONE(6309-61-1)
• EPA Substance Registry System: 1,4-DIHYDRO-6-METHYLQUINOXALINE-2,3-DIONE(6309-61-1)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Safety Statements: 24/25
• Hazardous Substances Data: 6309-61-1(Hazardous Substances Data)

Usage

General Description

1,4-Dihydro-6-methylquinoxaline-2,3-dione is a chemical compound with complex organic structures. This chemical compound belongs to the class of molecules known as quinoxalinones which are polycyclic aromatic compounds containing a benzene fused to a quinoxaline. Quinoxalines contain a ring system consisting of a benzene ring fused to a pyrazine ring. Its systematic name is 1,4-dihydro-6-methylquinoxaline-2,3(1H,4H)-dione. Further details on its physical properties, potential use, toxicity, and safety measures require more in-depth research and understanding of the compound.

InChI:InChI=1/C9H8N2O2/c1-5-2-3-6-7(4-5)11-9(13)8(12)10-6/h2-4H,1H3,(H,10,12)(H,11,13)

Upstream product

• 120-89-8 parabanic acid 
• 636-24-8 4-Methyl-benzene-1,2-diamine; hydrochloride 
• 144-62-7 oxalic acid 
• 496-72-0 4-methyl-1,2-diaminobenzene 
• 95-92-1 oxalic acid diethyl ester 
• 33368-89-7 6-methylquinoxaline 1,4-dioxide 
• 39267-05-5 2,3-dichloro-6-methylquinoxaline 
• 2439-01-2 morestan 
• 89-62-3 4-methyl-2-nitroaniline 
• 6153-56-6 oxalic acid dihydrate 

Downstream Products

• 39267-05-5 2,3-dichloro-6-methylquinoxaline 
• 1407513-30-7 2-chloro-6-methyl-3-(p-tolylethynyl)quinoxaline 
• 1407513-29-4 2-chloro-6-methyl-3-(phenylethynyl)quinoxaline 
• 1407513-35-2 6-methyl-2-p-tolyl-1H-pyrrolo[2,3-b]quinoxaline 
• 1407513-34-1 6-methyl-2-phenyl-1H-pyrrolo[2,3-b]quinoxaline 
• 1407513-37-4 6-methyl-1-(methylsulfonyl)-2-phenyl-1H-pyrrolo[2,3-b]quinoxaline 

Relevant articles and documents

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Novel molecular targeting anti-tumor aza-steroid derivative based on lipid toxicity and preparation and application thereof

The invention provides a novel molecular targeting anti-tumor aza-steroid derivative based on lipid toxicity and a preparation method and application thereof, and belongs to the field of chemical medicines. The derivative is a compound as shown in a formula I, or a salt thereof, or a stereoisomer thereof. The compound is low in toxicity or basically non-toxic to normal cells, has an obvious inhibition effect to tumor cell lines, particularly has good lipid toxicity selectivity to tumor cells such as liver cancer, lung cancer and the like in vivo, and has an obvious inhibition effect; meanwhile, the compound can effectively activate SREBP1 and PPAR gamma, inhibit lipid transport MTTP, cause lipid aggregation in tumor cells and cause lipid toxicity of the tumor cells. The compound can be used for treating liver cancer, lung cancer and the like in a molecular targeting manner, is low in toxicity or even non-toxic, and has a good application prospect.

Choline Chloride-based Eutectic Mixtures for Greener Synthesis of Quinoxaline-2,3-diol Derivatives and Terephthalaldehyde bis-(2-Aminophenylimine)

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A new solvent for the reaction of chlorination of hydroxyquinoxaline derivatives with vilsmeier reagent

A new efficient procedure for the chlorination of hydroxyquinoxaline derivatives into the corresponding chlorides is described. It has been found that the use of 1-chlorobutane produces the highest yield, reduces the time of reaction and facilitates direct formation of crystals without any purification.