1407513-30-7

Basic information

• Product Name: 2-chloro-6-methyl-3-(p-tolylethynyl)quinoxaline
• Synonyms: 2-chloro-6-methyl-3-(p-tolylethynyl)quinoxaline
• CAS NO: 1407513-30-7
• Molecular Weight: 292.768
• Mol File: 1407513-30-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-chloro-6-methyl-3-(p-tolylethynyl)quinoxaline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-6-methyl-3-(p-tolylethynyl)quinoxaline(1407513-30-7)
• EPA Substance Registry System: 2-chloro-6-methyl-3-(p-tolylethynyl)quinoxaline(1407513-30-7)

Safety Data

• Hazardous Substances Data: 1407513-30-7(Hazardous Substances Data)

Upstream product

• 39267-05-5 2,3-dichloro-6-methylquinoxaline 
• 766-97-2 4-n-methylphenylacetylene 
• 496-72-0 4-methyl-1,2-diaminobenzene 
• 6309-61-1 6-methylquinoxaline-2,3-dione 

Downstream Products

• 1407513-35-2 6-methyl-2-p-tolyl-1H-pyrrolo[2,3-b]quinoxaline 
• 1446433-01-7 (Z)-2-(2,4-diethoxy-3-methylphenyl)-3-(2-(2,4-diethoxy-3-methylphenyl)-2-p-tolylvinyl)-6-methylquinoxaline 
• 1446432-99-0 (Z)-2-(2,4-diethoxyphenyl)-3-(2-(2,4-diethoxyphenyl)-2-p-tolylvinyl)-6-methylquinoxaline 
• 1446432-97-8 (Z)-2-(2,4-dimethoxy-3-methylphenyl)-3-(2-(2,4-dimethoxy-3-methylphenyl)-2-p-tolylvinyl)-6-methylquinoxaline 
• 1446432-95-6 (Z)-2-(2,4-dimethoxyphenyl)-3-(2-(2,4-dimethoxyphenyl)-2-p-tolylvinyl)-6-methylquinoxaline 
• 1446432-93-4 (Z)-4-(3-(2-(2,4-dihydroxy-3-methylphenyl)-2-p-tolylvinyl)-6-methylquinoxalin-2-yl)-2-methylbenzene-1,3-diol 
• 1446432-91-2 (Z)-4-(3-(2-(2,4-dihydroxyphenyl)-2-p-tolylvinyl)-6-methylquinoxalin-2-yl)benzene-1,3-diol 

Relevant articles and documents

Ligand-free Pd-catalyzed C-N cross-coupling/cyclization strategy: An unprecedented access to 1-thienyl pyrroloquinoxalines for the new approach towards apoptosis

The link between PDE4 and apoptosis prompted us to design and synthesize for the first time a series of novel 1-thienyl pyrroloquinoxalines as potential PDE4 inhibitors/apoptotic agents. A ligand-free Pd-catalyzed C-N cross-coupling/cyclization strategy h

Palladium-Catalyzed Intramolecular Fujiwara-Hydroarylation: Synthesis of Benzo[a]phenazines Derivatives

An atom-economical Pd-catalyzed approach for the synthesis of benzophenazine derivatives using substituted 2-aryl-3-(aryl/alkylethynyl) quinoxaline in the presence of trifluoroacetic acid at 65 °C has been described. The chemistry involves in situ generation of cationic Pd(II) species, which functionalized the aromatic C-H bonds via electrophilic metalation followed by concomitant intramolecular trans-insertion of C-C triple bond to aryl-Pd complex. The results were supported by various control experiments including with electron-deficient arenes and deuterium labeling studies. The deuterium labeling studies supports electrophilic palladation of aromatic C-H over activation of C-C triple bond of alkyne. The structure of synthesized compounds was further confirmed by X-ray crystallography studies. This catalytic protocol has been efficiently applied for novel synthesis of highly functionalized benzo fused phenazines.

AlCl3-mediated hydroarylation-heteroarylation in a single pot: A direct access to densely functionalized olefins of pharmacological interest

An unprecedented AlCl3-mediated method has been developed involving aromatic C-H bond addition to an alkyne and heteroarylation of an arene in a single pot leading to densely functionalized novel olefins, e.g. 2-(2,2-diarylvinyl)-3-arylquinoxalines, as potential inhibitors of sirtuins.