1408327-48-9

Basic information

• Product Name: 5-methyl-2-nitro-6,7-dihydropyrazolo[1,5-a]pyrazine-4(5H)-one
• CAS NO: 1408327-48-9
• Molecular Weight: 196.166
• Mol File: 1408327-48-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-methyl-2-nitro-6,7-dihydropyrazolo[1,5-a]pyrazine-4(5H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methyl-2-nitro-6,7-dihydropyrazolo[1,5-a]pyrazine-4(5H)-one(1408327-48-9)
• EPA Substance Registry System: 5-methyl-2-nitro-6,7-dihydropyrazolo[1,5-a]pyrazine-4(5H)-one(1408327-48-9)

Safety Data

• Hazardous Substances Data: 1408327-48-9(Hazardous Substances Data)

Upstream product

• 74-89-5 methylamine 
• 109-83-1 (2-hydroxyethyl)(methyl)amine 
• 198348-89-9 5-nitropyrazole-3-carboxylic acid 
• 4535-90-4 N-methyl-2-chloroethylamine hydrochloride 

Downstream Products

• 1227210-32-3 5-methyl-2-nitro-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine 
• 1227210-33-4 5-methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-yl-amine 

Relevant articles and documents

CHEMICAL COMPOUNDS AS INHIBITORS OF INTERLEUKIN-1 ACTIVITY

The present disclosure relates to novel sulfonylurea and sulfonyl thiourea compounds and related compounds and their use in treating a disease or condition responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process.

A concise synthesis of a tetrahydropyrazolopyrazine building block

A concise synthesis of a tetrahydropyrazolopyrazine building block is described. 5-Methyl-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazin-2-ylamine was prepared in three steps and 80% yield from 5-nitro-2H-pyrazole-3-carboxylic acid. This compound was then coupled with 4-bromo-6-chloro-2-methyl-2H- pyridazin-3-one in the presence of sodium tert-pentoxide to give the target product in 87% yield. The process was successfully scaled up to a multihundred gram scale.