1409957-07-8

Basic information

• Product Name: 1-(2,2-difluoro-1-phenyl-2-(phenylsulfonyl)ethyl)piperidine
• Synonyms: 1-(2,2-difluoro-1-phenyl-2-(phenylsulfonyl)ethyl)piperidine
• CAS NO: 1409957-07-8
• Molecular Weight: 365.444
• Mol File: 1409957-07-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2,2-difluoro-1-phenyl-2-(phenylsulfonyl)ethyl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,2-difluoro-1-phenyl-2-(phenylsulfonyl)ethyl)piperidine(1409957-07-8)
• EPA Substance Registry System: 1-(2,2-difluoro-1-phenyl-2-(phenylsulfonyl)ethyl)piperidine(1409957-07-8)

Safety Data

• Hazardous Substances Data: 1409957-07-8(Hazardous Substances Data)

Upstream product

• 2538-76-3 1,1'-benzylidenedipiperidine 
• 536975-50-5 [difluoro(phenylsulfonyl)methyl](trimethyl)silane 

Downstream Products

• 1409957-82-9 1-(2,2-difluoro-1-phenylethyl)piperidine 

Relevant articles and documents

Nucleophilic difluoromethylation of N,N-acetals with TMSCF 2SO2Ph reagent promoted by trifluoroacetic acid: A facile access to α-difluoromethylated tertiary amines

A protocol for the synthesis of difluoromethylated tertiary amines by nucleophilic difluoromethylation of N,N-acetals using TMSCF2SO 2Ph reagent is developed. The reaction proceeds smoothly in 1,4-dioxane using K2CO3 as the initiator. A key feature of the reaction is that the in situ generated iminiums (from N,N-acetals and CF3COOH) could be fluoroalkylated in an efficient way.